Myelogenous Leukemia in the Rat |
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| Authors: | MOLONEY, WILLIAM C. DORR, ANDREW D. DOWD, GERALDINE BOSCHETTI, ANTONIO E. |
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| Affiliation: | 1 Research Laboratory, Holy Ghost Hospital, Cambridge, Mass., and the Hematology Laboratory (Tufts), Boston City Hospital, and the Department of Medicine, TuftsUniversity Medical School, Boston.
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| Abstract: | Observations on growth and other characteristics of subcutaneously transplanted chloroleukemia in non-inbred rats have been described in this report.This chloroleukemia cytologically is an acute or subacute, not chronic, myelogenous leukemia. Because of serious immunologic differences, the experimentalusefulness of subtransferred chloroleukemia is greatly limited. However,myelogenous leukemia in the rat, induced by chemical agents or ionizing radiation, may offer a valuable approach to the study of leukemogenic mechanisms. Submitted on June 23, 1961 Accepted on August 18, 1961 |
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