常见甲状腺良恶性肿瘤的形态定量分析

目的　探讨形态定量指标在常见甲状腺良恶性肿瘤鉴别诊断中的价值并建立数据库 ,为计算机协助诊断疾病打下基础。方法　利用PIPS -2 0 2 0型超清晰图象分析系统对 3 2例甲状腺良性乳头状增生病变 (TBPL)、3 2甲状腺乳头状腺癌 (TPAC)、2 7例甲状腺滤泡性腺瘤 (TFA)、2 4例甲状腺滤泡性腺癌 (TFAC)进行胞核形态定量研究。结果　TBPL与TPAC、TFA与TFAC、TBPL与TFA、TPAC与TFAC八项胞核形态定量参数经统计学处理比较 ,TBPL与TPAC的七项指标有非常显著性差异 (P <0 0 1)、TFA与TFAC的八项指标均有非常显著性差异 (P <0 0 1)、TBPL与TFA的 7项指标有非常显著性差异 (P <0 0 1) ;TPAC与TFAC的八项指标均无非常显著性差异 (P >0 0 1)。结论　形态定量参数可作为鉴别甲状腺常见良恶性肿瘤的参考指标。

Morphometric Quantitative Analysis of Common Thyroid Benign and Malignant Tumors

Objective To explore the value of morphometric quantitative parameters in differential diagnosis of common thyroid benign and malignant tumors, and establish a data bank as a basis for diagnosing diseases with the help of computer. Methods Using PIPS-2020 image analysis system to make a morphometric analysis in 32 cases of thyroid benign papillary lesion (TBPL), 32 cases of thyroid papillary adenocarcinoma(TPAC), 27 cases of thyroid follicular adenoma(TFA) and 24 cases of thyroid follicular adenocarcinoma(TFAC). Results Among many morphometric quantitative parameters of nuclei, eight including area, circumferential length, diameter,volume,long diameter, short diameter, largest to smallest diameter ratio, and circular rate were selected to analyze. The eight morphometric quantitative parameters between TFA and TFAC had a highly significant difference(P<0.01); seven ones between TBPL and TPAC, and between TBPL and TFA had a highly significant difference (P<0.01); and there was no significant difference in eight morphometric quantitative parameters between TPAC and TFAC (P>0.01). Conclusion These nuclear parameters have some value in differentiation of common thyroid benign and malignant tumors.