Indomethacin for prevention of stricture formation due to alkali-induced corrosive esophageal burns in the rat |
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| Authors: | Mehmet Pul Nuran Yilmaz Orhan Değer Naci Gürses |
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| Affiliation: | (1) Departments of Pediatric Surgery, Medical Faculty, Trabzon and Samsun, Turkey;(2) Departments of Pediatrics, Medical Faculty, Trabzon and Samsun, Turkey;(3) Deaprtments of Biochemistry of Karadeniz Technical and Ondokuzmayis Unversity, Medical Faculty, Trabzon and Samsun, Turkey |
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| Abstract: | The aim of this study was to investigate the therapeutic effect of indomethacin on corrosive esophageal strictures. Esophageal burns were produced in 40 of 50 Sprague-Dawley rats by 10.7% NaOH and were then grouped as pure esophageal burns, esophageal burns treated with indomethacin, and controls. All of the animals were killed on the 28th day of the experiment and hydroxyproline levels in esophageal tissue were determined for each rat. Hydroxyproline levels were significantly lower in the indomethacin-treated group than in the other two groups. Based on our results, we suggest that indomethacin inhibited collagen synthesis and thus alkali-induced esophageal stricture formation.Offprint requests to: M. Pul |
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| Keywords: | Indomethacin Esophageal stricture Caustic ingestion |
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