小剂量尿酸氧化酶治疗急性脑梗死的临床效果

①目的 探讨小剂量尿酸氧化酶治疗急性脑梗死的效果。②方法 将106例急性脑硬死病人随机分为治疗组56例，对照组50例。对照组应用脱水剂、活血化淤、脑保护剂及抗凝剂等治疗。治疗组在对照组的基础上加用小剂量尿酸氧化酶治疗。③结果 在治疗后24h，治疗组与对照组的临床评分差异无显著性（F＝4．66，q＝12．11，9．87，P＜0．05；F＝6．23，q＝17．83，11．91，P＜0．05；6h以内与7－24h溶栓治疗在7d，30d的临床评分也有显著性差异（q＝7．29，8．16，P＜0．05）。④结论 小剂量尿酸氧化酶治疗急性脑硬死在临床上有一定的疗效，并且安全、方便。溶剂时间越早效果越好。

EFFECTS OF SMALL DOSE UROKINASE ON ACUTE CEREBRAL INFARCTION

Objective To study the effects of urokinase on acute cerebral infarction . Methods 106 patients with acute cerebral infarction were randomly divided into Treated Group (56 cases ,regular therapy plus urokinase) and Control Group (50 cases , regular therapy ) . Results 24 hours after the treatment, the differences of clinical score between the two groups were not significant ( F=2.17, P >0.05) . The results showed that the difference of clinical score was significant after 7 and 30 day treatment of the two groups ( F=4.66, q=2.11, 9.87, P<0.05; F=6.23, q=17.83, 11.91, P <0.05) . The clinical score of thrombolytic therapy 7 and 30 days after the treatment showed significant difference for the patients treated within 6 hours as compared with those within 7-24 hours of the onset( q=7.29, 8.16, P <0.05). Conclusion Small dose of urokinase is effective, safe and simple clinically for acute cerebral infarction . The sooner use of urokinase, the better effect will be .