SARS-CoV-2-specific T cells in infection and vaccination |
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Authors: | Antonio Bertoletti Nina Le Bert Martin Qui Anthony T. Tan |
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Affiliation: | 1.Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore ;2.Singapore Immunology Network, A*STAR, Singapore, Singapore |
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Abstract: | During viral infections, antibodies and T cells act together to prevent pathogen spread and remove virus-infected cells. Virus-specific adaptive immunity can, however, also trigger pathological processes characterized by localized or systemic inflammatory events. The protective and/or pathological role of virus-specific T cells in SARS-CoV-2 infection has been the focus of many studies in COVID-19 patients and in vaccinated individuals. Here, we review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals. Understanding whether SARS-CoV-2-specific T cells are more linked to protection or pathogenesis is pivotal to define future therapeutic and prophylactic strategies to manage the current pandemic. |
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Keywords: | SARS-CoV-2 Vaccines T cells COVID-19 |
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