Allergy,Skin and Environment |
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| Institution: | 1. Baker IDI Heart and Diabetes Institute, Level 4, 99 Commercial Road, Melbourne 3004, Australia;2. Department of Epidemiology and Preventive Medicine, Monash University, Level 5, 99 Commercial Road, Melbourne 3004, Australia;3. The George Institute for Global Health, University of Sydney, Level 10, King George V Building, 83-117 Missenden Rd, Camperdown, NSW 2050, Australia;4. The George Institute for Global Health, Nuffield Department of Population Health, University of Oxford, UK;5. Department of Epidemiology, Johns Hopkins University, Baltimore, USA;6. School of Health and Social Development, Deakin University, 221 Burwood Highway, Burwood 3125, Australia |
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| Abstract: | The skin is very often the target organ of allergic reactions. This may be explained by many immunological competent cells in this organ such as the Langerhans cell, mast cells, lymphocytes, neutrophils and eosinophils. This is especially true for the antigen-presenting Langerhans cell. Therefore in many cases, the skin is a signalling organ for allergic reactions. Examples include food allergy which precipitates with signs and symptoms of skin diseases in about 45 % and drug allergy to β-lactam-antibiotics in about 90 %. Also the skin serves as a test organ in allergic diseases of other organs such as rhinitis allergica or asthma. Examples include Reibtest, prick-, intracutaneous-, scratch- and patch test. Therefore it is no surprise, that allergic diseases of the skin are the most often diagnosed skin diseases such as urticaria, angioedema, vasculitis, contact dermatitis and atopic dermatitis. At these diseases, their diagnose and therapy and especially the promissing progress in research with regard to these diseases which has been obtained during the last years will be focussed in this review. |
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