Suppressive effect of ultraviolet (UVB and PUVA) radiation on superantigen production by Staphylococcus aureus |
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| Affiliation: | 1. School of Electronic Information, Tianjin University, Key Laboratory of Opto-Electronics Information and Technical Science, Ministry of Education, Tianjin 300072, China;2. Physics Department, School of Science, Guizhou University, Guiyang, Guizhou 550025, China;1. V.V. Voevodsky Institute of Chemical Kinetics and Combustion, 3 Institutskaya str., 630090, Novosibirsk, Russian Federation;2. Novosibirsk State University, 2 Pirogova St., 630090, Novosibirsk, Russian Federation;3. International Tomography Center, 3a Institutskaya str., 630090, Novosibirsk, Russian Federation;1. Department of Physical and Theoretical Chemistry, Comenius University, 842 15 Bratislava 4, Mlynská Dolina, Slovakia;2. Department of Physical Chemistry, University of P. J. Šafárik in Košice, Moyzesova 11, 041 54 Košice, Slovakia;3. Institute of Materials Research, Slovak Academy of Sciences, Watsonova 1935/47, 040 01 Košice, Slovakia;4. Department of Condensed Matter Physics, University of P. J. Šafárik in Košice, Park Angelinum 9, 040 01 Košice, Slovakia;5. Department of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine and Pharmacy, Komenského 73, 043 85 Košice, Slovakia;6. Department of Chemistry, Loughborough University, Loughborough, Leics LE11 3TU, UK;1. Benemérita Universidad Autónoma de Puebla, Facultad de Ciencias Químicas, Av. San Claudio, Ciudad Universitaria, 72570 Puebla, PUE, Mexico;2. Universidade de Caxias do Sul, Área do Conhecimento de Ciências Exatas e Engenharias, Rua Francisco Getúlio Vargas, 1130, 95070-560 Caxias do Sul, RS, Brazil;1. Teagasc Food Research Centre Ashtown, Dublin 15, Ireland;2. School of Biosystems and Food Engineering, University College Dublin, Belfield, Dublin 4, Ireland |
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| Abstract: | It is well known that Staphylococcus aureus (S. aureus) proliferates on the moist skin lesion of atopic dermatitis. Reduction of bacteria colonization from skin lesions by antibiotics has been reported to be effective for the treatment of atopic dermatitis. S. aureus produces superantigens which can activate T cells and possibly enhance the inflammatory reaction. Photo(chemo)therapy has been successfully used for the treatment of severe cases of atopic dermatitis. We have previously reported that photo(chemo)therapy had bacteriostatic effect on S. aureus. Now we examined the effect of UVB and psoralen plus UVA (PUVA) on superantigen production from S. aureus. We isolated S. aureus from six atopic dermatitis patients. S. aureus was irradiated in vitro with UVB (0, 5, 10 mJ/cm2) or PUVA (0.001% psoralen plus 0, 5, 10 mJ/cm2 UVA) and incubated 4 h with 100 strokes per min. After incubation, the amounts of superantigens in the supernatant were measured using ELISA kit. The production of superantigens decreased in an ultraviolet dose-dependent manner. The suppressive effects of UV radiation on superantigen production may be involved in the therapeutic efficacy of photo(chemo)therapy for atopic dermatitis. |
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