Disposition of perphenazine is related to polymorphic debrisoquin hydroxylation in human beings |
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| Authors: | M L Dahl-Puustinen A Lidén C Alm C Nordin L Bertilsson |
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| Institution: | Department of Clinical Pharmacology, Karolinska Institute, Huddinge Hospital, Sweden. |
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| Abstract: | The pharmacokinetics of a single oral dose of 6 mg perphenazine was studied in a group of six slow and six rapid hydroxylators of debrisoquin. Peak serum concentrations of perphenazine were significantly higher in slow hydroxylators than they were in rapid hydroxylators (2.4 +/- 0.6 versus 0.7 +/- 0.3 nmol/L, p less than 0.001). The AUC(0-12) was also higher in slow hydroxylators than it was in rapid hydroxylators (18.5 +/- 6.2 versus 4.5 +/- 2.5 nmol.L-1.hr, p less than 0.001). The data suggest that the disposition of the antipsychotic drug perphenazine covaries with polymorphic debrisoquin hydroxylation. |
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