首页 | 本学科首页   官方微博 | 高级检索  
     

尸肾移植后应用他克莫司的临床观察
引用本文:郑克立,吴培根,朱兰英,费继光. 尸肾移植后应用他克莫司的临床观察[J]. 中华器官移植杂志, 2000, 21(3): 147-148
作者姓名:郑克立  吴培根  朱兰英  费继光
作者单位:中山医科大学附属第一医院器官移植中心,广州,510080
摘    要:目的 探讨肾移植后应用他克莫司(FK506)的方法、剂量、疗效及副作用。方法 30例尸肾移植患者术后应用他克莫司,临床观察3个月,监测血中他克莫司的浓度和副作用。结果 30例患者术后肾功能恢复均正常,在应用他克莫司的观察期内无排斥反应发生;血中他克莫司的浓度,3例为5~7μg/L,25例为8~15μg/L,2例为32~38μg/L;他克莫司的副作用主要为骨髓抑制和血糖升高。结论 他克莫司是一种强效

关 键 词:肾移植 免疫抑制剂 治疗结果 药物毒性 他克莫司

Clinical application of tacrolimus in 30 eases of cadaver renal transplantation
ZHENG Keli,WU Peigen,ZHU Lanying,et al.. Clinical application of tacrolimus in 30 eases of cadaver renal transplantation[J]. Chinese Journal of Organ Transplantation, 2000, 21(3): 147-148
Authors:ZHENG Keli  WU Peigen  ZHU Lanying  et al.
Affiliation:ZHENG Keli,WU Peigen,ZHU Lanying,et al. Department of Organ Transplantation,The First Affiliated Hospital,Sun Yat sen University of Medical Sciences,Guangzhou 510080,China
Abstract:Objectives To summarize the experiences of clinical use of tacrolimus as an alternative to cyclosporin in cadaver renal transplantation.Methods Blood concentrations and side effects of tacrolimus were observed for 3 months in 30 cases of cadaver renal transplantation.Results Renal functions were retumed to normal in the 30 cases after operation.No rejection occurred during the application of tacrolimus.The blood concentrations of tacrolimus were 5~7μg/L in 3 cases,8~15μg/L in 25 cases and 32-38μg/L in 2 cases,respectively.The main side effects of tacrolimus including marrow depression and hyperglycemia.Conclusions Tacrolimus is a highly effective immunosuppressive agent.When blood trough concentrations of tacrolimus are relatively low in the patients with normal renal function,there is no need to increase the dosage of tacmlinms.Tacrolimus is less harmful to liver and may be the best choice as an immunosuppressive therapy for patients with chronic hepatitis or abnormal liver function.
Keywords:Kidney transplantation  Immunosuppressive agents  Treatment outcome  Drug toxicity  
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号