丙泊酚对烧伤患者血小板活化反应的影响

目的 探讨丙泊酚对烧伤患者血小板活化反应的影响.方法 重度烧伤患者12例分为B1和B2组,每组6例;另选健康成人志愿者6例作为对照(C)组.抽收外周静脉血,分离血小板并洗涤.B1组加入生理盐水处理,B2组加入20μg/ml内泊酚,测定血小板血栓A_2(TxA_2)和肌醇-1,4,5-三磷酸酯(IP_3)水平,并测定血小板聚集率.结果 与C组相比,B1、B2组患者血小板TXA_2、IP_3水平明显升高,血小板聚集率也显著增高.B2组患者血小板TXA_2和IP_3含量均低于B1组(182.00±15.12)ng/10~9Plt vs.(243.90±21.52)ng/10~9Plt,(6.75±1.93)pmol/10~9PIt vs.(8.05±2.17)pnlol/10~9Plt],血小板聚集率也明显低于B1组(P<0.05).结论 丙泊酚可以抑制烧伤患者血小板的活化反应.

Effects of propofol on platelet activation in burn patients

Objective To investigate the effects of propofol on platelet(Plt) activation in burn patients.Methods Peripheral venous blood samples were taken from 12 severely burned patients and 6 healthy adult volunteers(group C) and platelets were separated and washed.Twenlvc severely burned patients were divided into two groups of B1 and B2 with 6 cases each.The Ph in group B1 was incubated with normal saline and in group B2 was incubated with propofol 20 μg/ml.The productions of TXA_2 and IP_3 were detected and Plt aggregation was measured.Results The contents of TXA_2 and IP_3 and the rate of Plt aggregation in groups of B1 and B2 were significantly higher than those in group C(P<0.05).The contents of TXA_2 and IP_3 were significantly lower in group B2 than those in group B1 F(182 ±15.12) ng/10~9 Plt vs.(243.90±21.52) ng/10~9Plt,(6.75±1.93) pmol/10±~9 Plt vs.(8.05±2.17) pmol/10±~9 Pht](P<0.05).So did the rate of Plt aggregation(P<0.05).ConclusionPropofol can inhibit Plt activation in severely burned patients.