The effect of acute aerobic exercise on pulse wave velocity and oxidative stress following postprandial hypertriglyceridemia in healthy men |
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Authors: | Conor M Mc Clean Jim Mc Laughlin George Burke Marie H Murphy Tom Trinick Ellie Duly Gareth W Davison |
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Institution: | (1) Sport and Exercise Sciences Research Institute, School of Sports Studies, University of Ulster, Shore Road, Newtownabbey, County Antrim, BT37 OQB, UK;(2) School of Electrical and Mechanical Engineering, University of Ulster Jordanstown, Shore Road, Newtownabbey, County Antrim, BT37 0QB, UK;(3) Department of Medicine, Ulster Hospital, Dundonald, Belfast, BT16 1RH, UK |
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Abstract: | Oxidative stress is postulated to be responsible for the postprandial impairments in vascular function. The purpose of this
study was to measure pulse wave velocity (PWV) and markers of postprandial oxidative stress before and after an acute bout
of moderate exercise. Ten trained male subjects (age 21.5 ± 2.5 years, VO2 max 58.5 ± 7.1 ml kg−1 min−1) participated in a randomised crossover design: (1) high-fat meal alone (2) high-fat meal followed 2 h later by a bout of
1 h moderate (60% max HR) exercise. PWV was examined at baseline, 1, 2, 3, and 4 h postprandially. Blood Lipid hydroperoxides
(LOOHs), Superoxide dismutase (SOD) and other biochemical markers were measured. PWV increased at 1 h (6.49 ± 2.1 m s−1), 2 h (6.94 ± 2.4 m s−1), 3 h (7.25 ± 2.1 m s−1) and 4 h (7.41 ± 2.5 m s−1) respectively, in the control trial (P < 0.05). There was no change in PWV at 3 h (5.36 ± 1.1 m s−1) or 4 h (5.95 ± 2.3 m s−1) post ingestion in the exercise trial (P > 0.05). LOOH levels decreased at 3 h post ingestion in the exercise trial compared to levels at 3 h (P < 0.05) in the control trial. SOD levels were lower at 3 h post ingestion in the control trial compared to 3 h in the exercise
trial (0.52 ± 0.05 vs. 0.41 ± 0.1 units μl−1; P < 0.05). These findings suggest that a single session of aerobic exercise can ameliorate the postprandial impairments in
arterial function by possibly reducing oxidative stress levels. |
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Keywords: | Exercise Postprandial lipaemia Oxidative stress Vascular function Lipid hydroperoxides |
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