MR Diagnosis of a Pulmonary Embolism: Comparison of P792 and Gd-DOTA for First-Pass Perfusion MRI and Contrast-Enhanced 3D MRA in a Rabbit Model |
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Authors: | Shella D Keilholz Ugur Bozlar Naomi Fujiwara Jaime F Mata Stuart S Berr Claire Corot and Klaus D Hagspiel |
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Institution: | 1.Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA.;2.Department of Radiology, University of Virginia Health System, Charlottesville, VA, USA.;3.Department of Radiology, Gulhane Military Medical Academy, Ankara, Turkey.;4.Guerbet Research, Aulnay-sous-Bois, France.;5.Department of Radiology, Kagawa University Faculty of Medicine, Kagawa, Japan.;6.Department of Diagnostic Radiology, Osaka Neurosurgical Hospital, Kagawa, Japan. |
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Abstract: | ObjectiveTo compare P792 (gadomelitol, a rapid clearance blood pool MR contrast agent) with gadolinium-tetraazacyclododecanetetraacetic acid (Gd-DOTA), a standard extracellular agent, for their suitability to diagnose a pulmonary embolism (PE) during a first-pass perfusion MRI and 3D contrast-enhanced (CE) MR angiography (MRA).Materials and MethodsA perfusion MRI or CE-MRA was performed in a rabbit PE model following the intravenous injection of a single dose of contrast agent. The time course of the pulmonary vascular and parenchymal enhancement was assessed by measuring the signal in the aorta, pulmonary artery, and lung parenchyma as a function of time to determine whether there is a significant difference between the techniques. CE-MRA studies were evaluated by their ability to depict the pulmonary vasculature and following defects between 3 seconds and 15 minutes after a triple dose intravenous injection of the contrast agents.ResultsThe P792 and Gd-DOTA were equivalent in their ability to demonstrate PE as perfusion defects on first pass imaging. The signal from P792 was significantly higher in vasculature than that from Gd-DOTA between the first and the tenth minutes after injection. The results suggest that a CE-MRA PE could be reliably diagnosed up to 15 minutes after injection.ConclusionP792 is superior to Gd-DOTA for the MR diagnosis of PE. |
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Keywords: | Pulmonary embolism P792 Angiography perfusion |
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