| RP-HPLC法测定复方珍珠含片中甘草酸的含量 |
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| 引用本文： | 龚金红,刘扬,储宁,张学农,阮华君,廖杰. RP-HPLC法测定复方珍珠含片中甘草酸的含量[J]. 抗感染药学, 2006, 3(3): 109-111 |
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| 作者姓名： | 龚金红 刘扬 储宁 张学农 阮华君 廖杰 |
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| 作者单位： | 苏州大学药学院,江苏,苏州,215123;浙江长生鸟药业有限公司,浙江,褚暨,311800 |
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| 摘 要： | 目的:建立复方珍珠含片中甘草酸含量测定的方法。方法:超声提取甘草酸,采用RP-HPLC法色谱条件为,ODS柱(4.6mm×250mm),流动相:乙腈-0.1%乙酸水溶液(33:67)波长254nm,流速1.0ml/min。结果:此方法线性关系,良好,甘草酸空白和加样平均回收率分别为99.42%(RSD1.36%),96.89%(RSD0.45%),日内RSD1.63%,日间RSD3.35%。结论:该法简便、快速、专属性强。
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| 关 键 词： | 珍珠含片 甘草酸 RP-HPLC |
| 文章编号： | 1672-7878（2006）03-0109-03 |
Determination of Glycyrrhizin in Zhenzhu Buccal Tablets by RP-HPLC |
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| GONG Jin-hong,LIU Yang,CHU Ning,ZHANG Xue-nong,RUAN Hua-jun,LIAO Jie. Determination of Glycyrrhizin in Zhenzhu Buccal Tablets by RP-HPLC[J]. Anti-infection Pharmacy, 2006, 3(3): 109-111 |
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| Authors: | GONG Jin-hong LIU Yang CHU Ning ZHANG Xue-nong RUAN Hua-jun LIAO Jie |
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| Abstract: | Objective:To establish an effective method for determination of glycyrrhizin in Zhenzhu buccal tablets. Methods: Glycyrrhizin in zhenzhu buccal tablets was determined by RP-HPLC (C18, AcetonitrileH2O(0.1% acetic acid)∶33:67, 1.0 ml/min, 254 nm) after Ultrasonic extracted with ethanol as media. Results: Linearity of this method was well (r=0.999 7); Average recovery was 96.89% (RSD 0.45%); precision of in-day and between-day were 1.63% and 3.35%, respectively. Conclusion: The established method for determination of glycyrrhizin in preparation is simple, fast and specific, and is applicable for quality control. |
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| Keywords: | Zhenzhu buccal tablets glycyrrhizin RP-HPLC |
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