Optimization of controlled drug release through interfacial polymerization

Interfacial nylon polymerization was chosen from the different in situ polymerization techniques to assess its utilization for controlled release medication. Sulfadiazine sodium was selected for such investigation, and several polymerization factors were altered during the technique stated. The pharmaceutical properties of the resulting products were used to evaluate the factor under consideration. The total product yield, as well as the product flowability were decidedly superior in the presence of either cross-linked gelatin or calcium alginate as aqueous phase modifiers during polymerization. Particle size was shown to increase depending upon the type and concentration of the included modifier. Scanning electron micrographs have confirmed morphologically the porous nature of the polymer coat. The latter displayed some pronounced effects on the first-order medicament dissolution kinetics.