Liquid-based endometrial cytology in the management of sonographically thickened endometrium |
| |
Authors: | Buccoliero Anna M Gheri Chiara F Castiglione Francesca Garbini Francesca Fambrini Massimiliano Bargelli Gianni Barbetti Alfredo Pappalardo Salvatore Taddei Antonio Boddi Vieri Scarselli Gian F Marchionni Mauro Taddei Gian L |
| |
Affiliation: | Department of Human Pathology and Oncology, University of Florence, Florence, Italy. ambuccoliero@unifi.it |
| |
Abstract: | Liquid-based cytology represents an opportunity to re-evaluate endometrial cytology. We evaluated the accuracy of liquid-based endometrial cytology as compared to biopsy in 670 women scheduled for histeroscopy because of thickened endometrium (>4 mm), as evaluated by transvaginal sonography. Endometrial biopsy detected pathology in 41 (6%) of cases (21 of which were adenocarcinomas). Cytologic study found pathology in 62 (9%) cases (19 of which were adenocarcinomas). Two hundred ninety-one biopsies (43%) and 28 (4%) cytologies were inadequate. The sensitivity and the specificity were estimated, respectively, at 95% and 98%; the positive and negative predictive values were estimated, respectively, at 83% and 99%. Cytology provided sufficient material more often than biopsy (P < 0.01). We consider endometrial cytology an efficacious diagnostic opportunity. It could be usefully applied in association with transvaginal sonography. The combination of these procedures might reduce more invasive and expensive diagnostic procedures. |
| |
Keywords: | thin‐layer liquid‐based endometrial cytology endometrial adenocarcinoma endometrial hyperplasia |
本文献已被 PubMed 等数据库收录! |