糖化血红蛋白在妊娠期糖尿病诊断中的临床应用

目的探讨糖化血红蛋白(HbAl)c在妊娠期糖尿病(GDM)诊断中的作用和意义。方法对正常妊娠组、妊娠糖尿病组(GDM)和糖耐量受损组进行空腹血糖(FPG)、糖筛查实验(GCT)、口服葡萄糖耐量实验(OGTT)和糖化血红蛋白(HbAlc)测定,并对结果进行回顾性分析。结果妊娠糖尿病组FPG,HbAlc和糖筛查实验结果与正常妊娠组及糖耐量受损组两组结果相比均明显增高,差异有显著性(P<0.05)。妊娠糖尿病组的HbAlc结果与OGTT实验结果阳性率无明显差异(P>0.05)。结论 HbAlc水平测定具有快速、简便、准确、取血量少的特点,并且不易受其他因素的影响,可作为临床GDM诊断筛查的指标。

Clinical Application of Glycosylated Hemoglobin in Diagnosis of Gestational Diabetes Mellitus

Objective To discuss the role and significance about glycosylated hemoglobin （HbAIc） in diagnosis of geslational diabetes mellitus. Methods Fasting blood glucose （FPG）, glucose screening test （GCT）, oral glucose tolerance test （OGTT） and glycosylated hemoglobin （HbAlc） were determinated in group of normal pregnancy, gestatinnal diabetes mellitus group（ GDM ） and impaired glucose tolerance group, and the results were retrospectively analyzed. Results Compared with normal pregnancy outcome and impaired glucose tnlerance gronp FPG, HhAlc and glucose screening test results of gestational diabetes mellitus group were significantly higher than the two groups,the difference was significant（P〈0.05）, HbAlc result of gestational diabetes group and the positive OGTT results was no significant difference（P〉0.05 ）. Conclusion Determination of HbAlc is fast,simple, accurate,and check the characteristics of a small amount of blood and are, not easily affected by other factors,can serve as a clinical diagnosis of GDM screening indicators.