血清IV型胶原和层粘连蛋白测定在结缔组织病中的意义

目的 探讨血清Ⅳ型胶原（ＩＶ．Ｃ）和层粘连蛋白（ＬＮ）在类风湿关节炎（ＰＡ）、系统性红斑狼疮（ＳＬＥ）和其它结缔组织病（ＣＴＤ）患者中的意义。方法 采用放射免疫法（ＰＩＡ）对３６例ＲＡ、３４例ＳＬＥ和１７例其它ＣＴＤ患者以及６３例正常人的血清ＩＶ．Ｃ和ＬＮ含量进行了测量。结果 各组患者血清ＩＶ．Ｃ和ＬＮ含量均较对照组明显升高（Ｐ〈０．０１～０．０００１），且ＳＬＥ组血清ＬＮ水平明显提高ＲＡ组（Ｐ〈

The value of detecting laminin and collagen IV in sera of patients with connective tissue disease

Objective To explore the clinical significance of laminin(LN) and collagen IV(IV·C) in sera of patientswith rheumatoid arthritis(RA),systemic lupus erythematosus(SLE) and other connective tissue diseases(CTD). Methods Asensitive radioimmunoassay was utilized to detect the level of IV·C and LN in sera of 36 patients with RA, 34 with SLE,17 with CTD and 63 normal individuals. Results The level of IV·C and LN elevated significantly in RA,SLE and CTD(P＜0.01～0. 0001)and the level of LN in SLE was obviously higher than that in RA(P＜0.05). There is a positive correlation be-tween serum IV·C and erythrocyte sedimentation rate(P＜0.05),a negative correlation between serum LN and albumin(P＜0. 005 ),a positive correlation between serum LN and globulin, complement C3 (P＜0.05～0. 001 ). Conclusion Serum IV· Cand LN may be considered as an important reference factor in evaluating the activity of connective tissue disease and becomeimmunopathogenic in developing progress of connective tissue disease.