Anti-ulcerogenic effect of banana powder (Musa sapientum var. paradisiaca) and its effect on mucosal resistance |
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| Authors: | R K Goel S Gupta R Shankar A K Sanyal |
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| Affiliation: | 1. Departments of Pharmacology, Banaras Hindu University, Varanasi 221005 India;2. Departments of Pathology, Banaras Hindu University, Varanasi 221005 India;3. Departments of Biochemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005 India;1. Department of Biotechnology, School of Life Sciences, Pondicherry University, Kalapet, Puducherry 605014, India;2. Department of Life Sciences, Yeungnan University, Gyeongsan, 712749, South Korea;3. Bio-Nanotechnology Laboratory, Department of Biotechnology, Faculty of Humanities and Sciences, SRM University, Kattankulatur, Chennai 603202, India;1. Bioactive Research Laboratory, Faculty of Pharmacy, Integral University, Lucknow 226026, India;2. Department of Pharmacology, King George Medical University, Lucknow 226003, India;3. Clinical Biochemistry and Natural Product Research Lab, Department of Biosciences, Integral University, Lucknow 226026, India;1. CICS-UBI – Health Sciences Research Centre, University of Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal;2. I3A – Aragón Institute of Engineering Research, Calle Mariano Esquillor, 50018 Zaragoza, Spain |
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| Abstract: | Orally administered banana pulp powder (Musa sapientum var. paradisiaca) was shown to have significant anti-ulcerogenic activity in rats subjected to aspirin, indomethacin, phenylbutazone, prednisolone and cysteamine and in guinea-pigs subjected to histamine. Banana powder not only increased mucosal thickness but also significantly increased [3H]thymidine incorporation into mucosal DNA. Relative to untreated control sections, histological studies showed that banana treatment increased staining by alcian blue in the apical cells with staining noted in the deeper layers of the mucosal glands. Banana-treated and control sections were also stained for DNA by the Feulgen reaction. The banana-treated sections showed a greater aggregation and intensity of pink spots when compared to controls. The present study suggests that banana powder treatment not only strengthens mucosal resistance against ulcerogens but also promotes healing by inducing cellular proliferation. |
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