Topical application of ionic polymers affects skin permeability barrier homeostasis |
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Authors: | Denda M Nakanishi K Kumazawa N |
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Affiliation: | Shiseido Research Center, 2-12-1 Fukuura, Kanazawa-ku, Yokohama, 236-8643, Japan. mitsuhiro.denda@to.shiseido.co.jp |
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Abstract: | We previously demonstrated that the external electric potential affected skin barrier homeostasis. On the other hand, topical application of an ionic polymer formed a diffusion electric double layer on the surface of the skin. Thus, we evaluated effects of topical application of ionic polymers on the damaged skin barrier. Application of a nonionic polymer did not affect barrier recovery. Application of sodium salts of anionic polymers accelerated barrier recovery, while that of cationic polymers delayed it. Topical application of a sodium-exchange resin accelerated barrier recovery, but application of a calcium-exchange resin had no effect even when the resins had the same structure. Application of a chloride-exchange resin delayed barrier recovery. Topical application of ionic polymers influenced skin barrier homeostasis. |
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