| 东亚钳蝎毒素的镇痛作用与吗啡镇痛作用的比较 |
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| 摘 要： | 用辐射热甩尾反射测定大鼠痛阈的方法，观察并比较了东亚钳蝎毒素和吗啡的镇痛作用。结果表明：向侧脑室内注射２μＬ或肌肉注射０．０５μＬ、０．０１％蝎毒液的镇痛作用分别比相同给药途径、同浓度、同剂量吗啡的镇痛作用强，二者差异非常显著，Ｐ＜０．０ｌ。侧脑室内注射０．０３％蝎毒液２μＬ的镇痛作用比同浓度、同剂量吗啡的镇痛作用梢强，但无显著差异，Ｐ＞０．０５。蝎毒经肌肉注射后在较短的时间内即可使大鼠痛阈明显升高。证明蝎毒可通过血脑屏障进入中枢神经系统，产生镇痛作用。
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| 关 键 词： | 东亚钳蝎毒素，吗啡，侧脑室注射，肌肉注射，痛阈，镇痛作用 |
CoMparison of analgesic effect of scorpion venom from Buthus martensii Karsch(BmK)with
morphine |
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| Authors: | Liu Minzhi Wei Junjie Song Hongchen |
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| Institution: | Dept.of Physiology; Dept.of Organic
Chemistry |
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| Abstract: | The experimental results showed that the analgesic effect of 0.0l% BmK
venom in-jected either into lateral cerebral ventricle or intramuscularly was significantly
stronger than that ofmorphine under entirely the same condition,P<0.01. The analgesic effect of
0. 03% BmK venom in-jected into lateral cerebral ventricle was sliglitly stronger than that of
0.03% morphine,the differencebeing not so significant ,P<0. 05.The rise in pain threshold after
injecting BmK venom intramuscu-larly with a delay of only a few minutes indicated that the
BmK venom could permeate the blood-brain barrier into central nervous system to produce the
analgesic effect. |
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| Keywords: | scorpion venom of Buthus martensii Karphine injection into lateral cerebral ventricle intramuscular injection pain threshold analgesic effect |
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