山东省608例HIV/AIDS病人抗病毒治疗结果分析

目的了解2003-2010年山东省接受艾滋病抗病毒治疗且目前仍在治疗的艾滋病病毒（HIV）感染者/艾滋病（AIDS）病人（HIV/AIDS病人）的治疗结果。方法收集2010年12月底前开始接受AIDS抗病毒治疗且目前仍在治的HIV/AIDS病人的随访资料,描述分析其一般情况,治疗前和治疗后不同时间段的CD4＋T淋巴细胞计数、病毒载量和机会性感染发生状况等。结果山东省2003-2010年接受AIDS抗病毒治疗且目前仍在治疗的HIV/AIDS病人608例,其中男性占65.6%（399/608）,女性占34.4%（209/608）,平均年龄为（40.2±10.2）岁,已婚或同居者占65.5%（398/608）;感染途径以异性性接触感染为主,占44.9%（273/608）,其次是同性性接触感染,占21.1%（128/608）;有182例更换了抗病毒治疗药物,占29.9%,换药主要原因为药物不良反应。基线时CD4＋T淋巴细胞平均计数≤200个/μL的占65.8%,200～350个/μL的占33.0%,≥350个/μL的占1.2%,同基线时相比,治疗前、治疗3个月、6个月、1年、2年、3年时CD4＋T淋巴细胞计数均有增加（P〈0.05）。治疗后病毒载量低于检出限的比例增高,机会性感染发生率降低。结论抗病毒治疗可有效提高HIV/AIDS病人的免疫力,有利于提高其生命质量。

Result analysis of antiviral therapy in 608 HIV/AIDS cases from Shandong

Objective To analyze the outcome among human imnunodeficiency virus/acquired immunodeficiency syndrome（HIV/AIDS） cases receiving antiretroviral treatment from 2003 to 2010 and living with the treatment in Shandong Province. Methods Follow-up data of HIV/AIDS cases beginning AIDS antiretroviral treatment before the end of December 2010 and still in the treatment were collect, and to analyze the general status and the dynamic changes of CD＋ T cell counting, viral load, the status of opportunistic infections at different stages. Results Total ly 608 subjects receiving antiretroviral treatment from 2003 to 2010 and living with treatment were involved, of whom males were 399 （65.6%）, females were 209 （34.4%） ,the average age of them was （40.2±10.2）. Most of the subjects were married or cohabited, accounting for 65.5%. 44.9 % of the subjects were infected by heterosexual transmission, 21.1% were homosexually transmitted. 182 cases changed antiviral therapy （29.9 %） because of the drugs＇ side reaction. Compared with the baseline, CD4＋ T lymphocyte increased significantly at different stages of treatment in the respective of before treatment, treating for three months, six months, one year, two years and three years （P〈0.05）. At the baseline, 65.8% with CD4＋T lymphocyte count ≤200/μL, 33.0% were 200-350/ μL, 1.2% were ≥≥350/μL. After the antiviral therapy, the percentage of HIV/AIDS cases with viral load lower than the detection limit were raised, and the incidence of opportunistic infections were also reduced. Conclusion Antiretroviral treatment can promote the immune reconstruction and the patients＇ life quality.