深圳市光明新区孕妇梅毒感染状况及危险因素分析

目的了解深圳市光明新区孕妇梅毒感染状况并分析其危险因素。方法对所有首次到医院进行产前检查的孕妇,采用梅毒甲苯胺红不加热血清试验（TRUST）进行初筛,阳性血清采用梅毒螺旋体明胶颗粒凝集试验（TPPA）进行确认;再采用单因素Logistic和非条件多因素Logistic回归分析。结果 2003年1月至2011年11月,梅毒免费筛查孕妇60 992人,检出梅毒阳性孕妇400人,阳性率0.66%。单因素分析显示,孕妇的户籍、文化程度、性伴文化程度、职业、不良妊娠结局史、泌尿生殖道炎症、近5年性伴数、性伴近5年的性伴数、首诊孕周等,与孕妇梅毒的发生有统计学意义。多因素分析发现,职业、不良妊娠结局史、近5年性伴数、性伴近5年性伴数和首诊孕周,是孕妇梅毒发病的独立危险因素。结论深圳市光明新区孕妇人群梅毒感染率处于较高水平,加强性病健康教育、改善就医条件以及关心育龄人群的业余生活等,有助于降低发病率。

Study on the syphilis infection status and related risk factors among pregnant women in Guangming New District, Shenzhen City

Objective To investigate the syphilis infection status among pregnant women in Guangming New District, Shenzhen City and evaluate related risk factors. Methods All pregnant women in Guangming New District seeking antenatal care for the first time were included in the study. Toluidine red unheated serum test（TRUST） was used for primary screening and positive results were confirmed by treponema pallidum particle agglutination （TPPA）. Logistic regression was used for data analysis. Results From Jan. 2003 to Nov. 2011, totally 60 992 pregnant women received syphilis screening, of them 400 were tested syphilis positive, the positive rate was 0.66 %. As shown by single factor analysis, the risk factors associated with pregnant syphilis were household register,education background of the pregnant women themselves and their sex partners, occupation, history of adverse pregnancy outcome, urogenital infection, number of sex partners of women themselves and number of sex partners of their partners in the recent five years and gestational weeks at the first visit. Multivariate unconditional logistic regression analysis showed that occupation, history of adverse pregnancy outcome, number of sex partners of women themselves and number of sex partners of their partners in the recent five years, and gestational weeks at the first visit were the five independent risk factors. Conclusion The syphilis infection rate among pregnant women in Guangming New District is at a high level. Strengthening health education on sexually transmitted diseases （STD）, improving medical seeking conditions and providing proper care for the spare time life of child-bearing age people will reduce the prevalence of STD.