Acute respiratory failure following pharmacologically induced hyperventilation: an experimental animal study |
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Authors: | D. Mascheroni T. Kolobow R. Fumagalli M. P. Moretti V. Chen D. Buckhold |
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Affiliation: | (1) National Heart, Lung and Blood Institute, Laboratory of Technical Development, National Institutes of Health, Bethesda, Maryland, USA;(2) Present address: Istituto di Anestesiologia e Rianimazione, Università degli Studi di Milano, Via F. Sforza 35, I-20121 Milano, Italy;(3) Present address: Ospedale civile di Legnano, Servizio di Anestesiologia, Legnano, (MI), Italy |
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Abstract: | The pulmonary effects of hyperventilation following infusion of sodium salicylate into the cisterna magna was studied in 16 spontaneously breathing adult sheep. We found a fall in PaO2, a decrease in the static compliance of the respiratory system, abnormal chest roentgenographic films, and grossly abnormal lungs following 3.5 to 13 h of hyperventilation. A control group of 15 sheep (10 sheep similarly injected with sodium salicylate, but then sedated and paralyzed and ventilated at normal tidal volume and respiratory rate on a mechanical ventilator, and 5 sheep infused with saline alone and breathing spontaneously) showed no pulmonary or arterial blood gas abnormalities. We conclude that prolonged hyperventilation under the conditions of this experiment precipitated events that resulted in acute lung injury. |
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Keywords: | Hyperventilation Sodium salicylate Acute respiratory failure Lung injury |
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