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Recurrent 'Migrainelike' Episodes in Patients With HIV Disease |
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| Authors: | Dr.,Rita Rinaldi,MD Roberto Manfredi,MD, Giuseppe Azzimondi,MD, Giuseppina Rodorigo,MD, Caterina Tonon,MD, Vincenzo De,Rosa,MD Antonio Mastroianni,MD, Olga V. Coronado,MD, Cristina Legnani,MD, Francesco Chiodo,MD, Roberto D'Alessandro,MD |
| Affiliation: | Neurology Unit University of Bologna, Italy.;Department of Clinical and Experimental Medicine, Division of Infectious Diseases University of Bologna, Italy.;Department of Angiology and Coagulation Disorders, University of Bologna, Italy. |
| Abstract: | Recurrent transient neurological deficits have been described in human immunodeficiency virus (HIV)-infected subjects, but their frequency, pathogenesis, and outcome are still unsettled. We describe 10 HIV-infected patients with transient neurological deficits (0.8% of all patients followed in ourdepartment during the last decade). All patients were in the advanced stage of immunological disease. None of theclinical or special investigations performed outside of the attacks indicated an underlying structural lesion of the centralnervous system. In 80% of these patients, anticardiolipin antibodies were present. The final outcome was unrelated tothese transient neurological deficits which, per se, had a benign course. We discuss the possible etiopathogenetic mechanisms of such episodes and suggest that they may be "migrainelike"events, possibly related to transient functional circulatory abnormalities secondary to an immunologicalantiphospholipid antibody-dependent mechanism. |
| Keywords: | human immunodeficiency virus (HIV) infection transient neurological deficits transient ischemic attacks migraine outcome |