三种方案在食管癌化疗中的成本效果分析及临床评价

目的评价三种以植物来源抗肿瘤药物为主的方案在食管癌化疗中的经济学效果和临床作用特点。方法采用回溯法筛选了111例食管癌病例,分为3组。Ⅰ组采用PVB方案化疗,Ⅱ组采用TD方案化疗,Ⅲ组采用PEF方案化疗。运用药物流行病学的疗效比较和药物经济学的成本-效果分析方法进行研究。结果3组有效率分别为55.56%、47.36%、43.24%;成本效果比分别为380.13、423.45、379.46元。结论PVB方案具有积极的药物经济学意义。

COST-EFFECTIVENESS ANALYSIS AND CLINICAL EVALUATION OF THREE THERAPEUTIC REGIMENS IN CHEMOTHERAPY FOR ESOPHAGEAL CARCINOMA

Objective To evaluate the economic impact and clinical effect of three plant-resource anti-tumor drugs in chemotherapy for esophageal carcinoma. Methods A retrospective review was done in 111 patients who were randomly divided into three groups. Group Ⅰ was treated with PVB （vindesine, bleomycin and cisplatin） ; group Ⅱ with TD （taxol and cisplatin） and group Ⅲ with PEF（VP-J6, 5 FU and cisplatin）. The study was done by using pharmacoepidemiological therapeutic ratio and pharmacoeconomic cost-effectiveness analysis. Results The effective power was 55. 56%, 47. 36 % and 43. 24 %, respectively, for groups Ⅰ , Ⅱ and Ⅲ. The cost-effectiveness ratio was 380.13, 423.45 and 379.46, respectively, for the three groups. Conclusion PVB therapy is of active pharmacoeconomic significance for esophageal carcinoma.