(1) Division of Clinical Epidemiology, McGill University Health Centre Research Institute, Montreal, Canada;(2) Division of Medical Oncology, McGill University Health Center, Montreal, Canada
Abstract:
Background
Eighty percent of all breast cancers and almost 90% of breast cancer deaths occur among post-menopausal women. We used a nested case control design to examine the association between nonsteroidal anti-inflammatory drug (NSAID) use and breast cancer occurrence among women over 65 years of age. The cyclooxygenase (COX)-2 enzyme is expressed more in breast cancers than in normal breast tissue. COX-2 inhibition may have a role in breast cancer prevention.
