长期配戴软性角膜接触镜对角膜内皮细胞的影响

目的 评价长期(≥10年)持续配戴软性角膜接触镜(SCL)对角膜内皮细胞的影响,更好地长期持续配戴SCL者进行眼病治疗及内眼手术前的评估.方法 利用非接触式角膜内皮显微镜(TOP-CON SP-2000P),观察长期配戴SCL的98只眼角膜内皮细胞的改变.同年龄组无其他疾患非戴SCL近视眼的角膜内皮细胞参数作为对照观察.结果 长期持续配戴SCL组角膜内皮细胞密度为2516.58±311.77,角膜内皮细胞面积变异系数(CV)为28.10±3.76,角膜内皮六角形细胞比例(6A%)为(48.90±6.10)%,与无SCL配戴史组比较差异均有统计学意义(P=0.02,P＜0.01,P＜0.01).结论 长期持续佩戴SCL组与无SCL佩戴史组对比在角膜内皮细胞数量和形态上的差异均有统计学意义,相比之下长期持续佩戴SCL对CV和6A%的影响更为显著.因此对长期持续配戴SCL患者进行可能引起内皮细胞损失的眼疾治疗和手术时应选择合理的药物和相对安全的手术方式,避免角膜内皮失代偿的发生.同时也建议近视患者尽量避免长时间持续佩戴SCL以保证角膜内皮的健康.

Abstract：

Objective To investigate long term effects (≥ 10years) of soft contact lens (SCL) wear on the corneal endothelium in order to evaluate the risk before a treatment and an operation better.Methods Non-contact specular microscopy (TOPCON SP-2000P) was performed on long-term (≥ 10years) SCL wearers and the control group.Results After more than 10 years SCL wearing,cell density was 2516.58± 311.77,CV was 28.10± 3.76 and 6A% was (48.90± 6.10)%.There was statistically difference (P =0.02,P ＜0.01,P ＜0.01) compared with those of the control.Conclusion Long-term soft contact lens wear produce cell loss and cell shape change,and the cell shape changes are more remarkable.We should choose safer surgery and medicine for the patients with long-term soft contact lens wear.At the same time,we also suggest that myopia sufferer should avoid wearing SCL consistently for a long term.

Long term effects of soft contact lens wear on the corneal endothelium

Objective To investigate long term effects (≥ 10years) of soft contact lens (SCL) wear on the corneal endothelium in order to evaluate the risk before a treatment and an operation better.Methods Non-contact specular microscopy (TOPCON SP-2000P) was performed on long-term (≥ 10years) SCL wearers and the control group.Results After more than 10 years SCL wearing,cell density was 2516.58± 311.77,CV was 28.10± 3.76 and 6A% was (48.90± 6.10)%.There was statistically difference (P =0.02,P ＜0.01,P ＜0.01) compared with those of the control.Conclusion Long-term soft contact lens wear produce cell loss and cell shape change,and the cell shape changes are more remarkable.We should choose safer surgery and medicine for the patients with long-term soft contact lens wear.At the same time,we also suggest that myopia sufferer should avoid wearing SCL consistently for a long term.