前节OCT评估抗生素滴眼液对泪河的影响

目的 利用前节OCT探讨点用抗生素滴眼液后泪河的变化,以期指导临床合理用药.方法 使用前节光学相干断层扫描(OCT)测量点用左氧氟沙星和0.3%盐酸左氧氟沙星透明质酸钠(SA)滴眼液前后泪河的参数,比较其变化.结果 青年近视患者眼泪液截面积为平均为(0.038±0.029)mm2,泪河深度(TMD)平均为(193.70±62.35)μm,泪河高度(TMH)平均为(302.79±121.72)μm.点用左氧氟沙星后泪液截面积为平均为(0.023±0.011)mm2,泪河深度平均为(160.81±44.98)μm,泪河高度平均为(238.26±54.33)μm,均比点药前减少,差异有统计学意义(P＜0.01);点用0.3%盐酸左氧氟沙星透明质酸钠滴眼液后泪液截面积为平均为(0.025±0.014)mm2,泪河深度平均为(164.85±49.71)μm,泪河高度平均为(242.19±66.15)μm,均比点药前减少,差异有统计学意义(P＜0.05);点药前后双眼之间上述指标差异没有统计学意义(P＞0.05).结论 点用左氧氟沙星滴眼液和0.3%盐酸左氧氟沙星透明质酸钠滴眼液均会减少泪河截面积、高度和深度,提示临床抗生素滴眼液应合理使用,适时保护泪膜.

Abstract：

Objective To study the change of tear meniscus arer antibiotic eye drops with optical coherence tomography and to instruct clinical usage of antibiotic eye drops properly.Methods Optical coherence tomography was used to measure tear meniscus before and after drop levofloxacin or 0.3% levofloxacin hydrochloride sodium hyaluronate,and the changes were compared.Results The cross-section of the inferior tear meniscus in myopic eye of young people was 0.038±0.029 mm2,tear meniscus depth was(193.70±62.35)μ m and tear meniscus height was(302.79± 121.72)μ m.The inferior tear meniscus decreased after drop levofloxacin.The cross-section of the inferior tear meniscus was(0.023± 0.011)mm2,tear meniscus depth was(160.8 1± 44.98)μ m,tear meniscus height was(238.26± 54.33)μ m,and they all had statistical difference with no eye drops(P ＜0.01).The inferior tear meniscus decreased after drop 0.3% levofloxacin hydrochloride SA.The cross-section of the inferior tear meniscus was(0.025 ± 0.014)mm2,tear meniscus depth was (164.85± 49.71)μ m,tear meniscus height was(242.19± 66.15)μ m and there was statistical difference between the same eye before and after using the eye drops(P ＜0.05),and there was no statistical difference between both eyes pre and after using the eye drops(P ＞0.05).Conclusions The tear meniscus cross-section,depth and height decrease after using drop levofloxacin and 0.3% levofloxacin hydrochloride SA which suggests that antibiotic eye drops should be used rationally in order to care and protect tear film properly in clinic.

Effect of antibiotic eye drops on tear meniscus with Anterior Segment OCT

Objective To study the change of tear meniscus arer antibiotic eye drops with optical coherence tomography and to instruct clinical usage of antibiotic eye drops properly.Methods Optical coherence tomography was used to measure tear meniscus before and after drop levofloxacin or 0.3% levofloxacin hydrochloride sodium hyaluronate,and the changes were compared.Results The cross-section of the inferior tear meniscus in myopic eye of young people was 0.038±0.029 mm2,tear meniscus depth was(193.70±62.35)μ m and tear meniscus height was(302.79± 121.72)μ m.The inferior tear meniscus decreased after drop levofloxacin.The cross-section of the inferior tear meniscus was(0.023± 0.011)mm2,tear meniscus depth was(160.8 1± 44.98)μ m,tear meniscus height was(238.26± 54.33)μ m,and they all had statistical difference with no eye drops(P ＜0.01).The inferior tear meniscus decreased after drop 0.3% levofloxacin hydrochloride SA.The cross-section of the inferior tear meniscus was(0.025 ± 0.014)mm2,tear meniscus depth was (164.85± 49.71)μ m,tear meniscus height was(242.19± 66.15)μ m and there was statistical difference between the same eye before and after using the eye drops(P ＜0.05),and there was no statistical difference between both eyes pre and after using the eye drops(P ＞0.05).Conclusions The tear meniscus cross-section,depth and height decrease after using drop levofloxacin and 0.3% levofloxacin hydrochloride SA which suggests that antibiotic eye drops should be used rationally in order to care and protect tear film properly in clinic.