| 黄芪多糖颗粒防潮辅料的研究 |
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| 引用本文： | 李小芳,何倩灵,向永臣,李剑,苏娟. 黄芪多糖颗粒防潮辅料的研究[J]. 中国实验方剂学杂志, 2011, 17(9): 11-14 |
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| 作者姓名： | 李小芳 何倩灵 向永臣 李剑 苏娟 |
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| 作者单位： | 成都中医药大学中药材标准化教育部重点实验室,中药资源系统研究与开发利用省部共建国家重点实验室教育基地,成都,611137 |
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| 摘 要： | 目的:优选黄芪多糖颗粒的最佳防潮辅料及其配比。方法:以黄芪多糖为模型药物,单因素法考察单一辅料和混合辅料对黄芪多糖吸湿性的影响,筛选出辅料的种类及配比,并测定其临界相对湿度。结果:综合吸湿性、成型性和外观性状,以乳糖-微晶纤维素-甘露醇(2∶1∶1)的防潮效果最好,并测其临界相对湿度为66%。结论:筛选出的防潮辅料能有效的降低多糖类成分的吸湿性。
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| 关 键 词： | 中药固体制剂 吸湿性 防潮辅料 |
| 收稿时间： | 2010-07-02 |
Study on Damp-proofing Excipients of APS Granules |
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| LI Xiao-fang,HE Qian-ling,XIANG Yong-chen,LI Jian and SU Juan. Study on Damp-proofing Excipients of APS Granules[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(9): 11-14 |
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| Authors: | LI Xiao-fang HE Qian-ling XIANG Yong-chen LI Jian SU Juan |
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| Affiliation: | Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicines, System of Traditional Chinese Medicine Resoures and Development Utilization of Ministry of State Key Laboratory Breeding Base, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicines, System of Traditional Chinese Medicine Resoures and Development Utilization of Ministry of State Key Laboratory Breeding Base, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicines, System of Traditional Chinese Medicine Resoures and Development Utilization of Ministry of State Key Laboratory Breeding Base, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicines, System of Traditional Chinese Medicine Resoures and Development Utilization of Ministry of State Key Laboratory Breeding Base, Chengdu 611137, China;Chengdu University of Traditional Chinese Medicine, Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicines, System of Traditional Chinese Medicine Resoures and Development Utilization of Ministry of State Key Laboratory Breeding Base, Chengdu 611137, China |
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| Abstract: | Objective:To select the best ratio of damp-proofing excipients for astragalus polysaccharides(APS) granules.Method: APS was chosen as a model drug.The influence of single and blended excipients on hygroscopicity of APS was studied with the method of single factor test to screen the kinds and ratio of the excipients and measure its critical relative humidity.Result: The best damp-proofing excipients integrated with hygroscopicity,formability and appearance were lactose,microcrystalline cellulose and mannitol... |
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| Keywords: | solid dosage of traditional Chinese medicine hygroscopicity damp-proofing excipients |
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