Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio are
Predictors of Heart Failure |
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Authors: | Erdal Durmus Tarik Kivrak Fethullah Gerin Murat Sunbul Ibrahim Sari Okan Erdogan |
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Institution: | 1.Silifke State Hospital, Cardiology Clinic, Mersin, Turkey;2.Sivas Numune Hospital, Cardiology Clinic, Sivas, Turkey;3.Central Laboratory of Public Health, Department of Clinical Biochemistry, Istanbul, Turkey;4.Marmara University Faculty of Medicine, Department of Cardiology, Istanbul, Turkey |
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Abstract: | BackgroundNeutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are
inflammatory markers used as prognostic factors in various diseases. The aims of
this study were to compare the PLR and the NLR of heart failure (HF) patients with
those of age-sex matched controls, to evaluate the predictive value of those
markers in detecting HF, and to demonstrate the effect of NLR and PLR on mortality
in HF patients during follow-up.MethodsThis study included 56 HF patients and 40 controls without HF. All subjects
underwent transthoracic echocardiography to evaluate cardiac functions. The NLR
and the PLR were calculated as the ratio of neutrophil count to lymphocyte count
and as the ratio of platelet count to lymphocyte count, respectively. All HF
patients were followed after their discharge from the hospital to evaluate
mortality, cerebrovascular events, and re-hospitalization.ResultsThe NLR and the PLR of HF patients were significantly higher compared to those of
the controls (p < 0.01). There was an inverse correlation between the NLR and
the left ventricular ejection fraction of the study population (r: -0.409, p <
0.001). The best cut-off value of NLR to predict HF was 3.0, with 86.3%
sensitivity and 77.5% specificity, and the best cut-off value of PLR to predict HF
was 137.3, with 70% sensitivity and 60% specificity. Only NLR was an independent
predictor of mortality in HF patients. A cut-off value of 5.1 for NLR can predict
death in HF patients with 75% sensitivity and 62% specificity during a 12.8-month
follow-up period on average.ConclusionNLR and PLR were higher in HF patients than in age-sex matched controls. However,
NLR and PLR were not sufficient to establish a diagnosis of HF. NLR can be used to
predict mortality during the follow-up of HF patients. |
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Keywords: | Heart Failure / blood Heart Failure / diagnosis Multivariate Analysis Neutrophils / cytology Leukocyte Count Lymphocyte Count |
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