Comparative study of the subserosal versus submucosal dye injection method for sentinel node biopsy in gastric cancer |
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| Affiliation: | 1. University of Colorado School of Medicine, Department of Surgery, Aurora, CO, USA;2. University of Colorado School of Medicine, Department of Pathology, Aurora, CO, USA;3. Accords, Aurora, CO, USA;4. University of Colorado School of Medicine, Department of Oncology, Lone Tree, CO, USA;5. University of Colorado School of Medicine, Department of Surgery, Division of Plastic & Reconstructive Surgery, Aurora, CO, USA;1. Department of Research, Netherlands Comprehensive Cancer Organisation, Eindhoven, The Netherlands;2. Department of Public Health, Erasmus MC, Rotterdam, The Netherlands;3. Department of Internal Medicine, Catharina Hospital, Eindhoven, The Netherlands;4. Department of Internal Medicine, Jeroen Bosch Hospital, ''s-Hertogenbosch, the Netherlands;5. Department of Geriatric Medicine, Elisabeth-TweeSteden Hospital, Tilburg, The Netherlands;6. Department of Clinical Epidemiology, VieCuri Medical Centre, Venlo, the Netherlands;7. Department of Epidemiology, Maastricht UMC, GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands;1. Department of Surgery, Seoul National University Bundang Hospital, Seoul, Republic of Korea;2. Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea;3. Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seoul, Republic of Korea;4. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seoul, Republic of Korea;5. Department of Urology, Seoul National University Bundang Hospital, Seoul, Republic of Korea;6. Office of Digital Medicine, Seoul National University Bundang Hospital, Seoul, Republic of Korea;1. South Nassau Communities Hospital, Department of Surgery, United States;2. New York Instituite of Technology, Collage of Osteopathic Medicine, United States;3. Ross University School of Medicine, United States;1. General and Oncology Surgery Unit, Intestinal Failure Center, Stanley Dudrick''s Memorial Hospital, Skawina, Poland;2. Clinical Nutrition Department, M. Pirogow Hospital, Lodz, Poland;3. Department of General Surgery and Clinical Nutrition Medical University of Warsaw, Poland;4. Centre for Intestinal Failure, Department of General, Endocrinology and Gastroenterological Surgery, Poznan University of Medical Science, Poznan, Poland;5. The Regional Specialist Hospital in Olsztyn, Center for Clinical Nutrition, Olsztyn, Poland |
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| Abstract: | AimsTo determine the most efficient injection method for a sentinel node (SN) biopsy in gastric cancer.MethodsGastric adenocarcinoma patients without serosal invasion and distant metastasis were prospectively enrolled in this study. Isosulfan blue was injected into the subserosa (SS) of the first set of 71 consecutive patients and an intraoperative endoscopic submucosal (SM) injection of the same dye was injected into the second set of 50 consecutive patients. After the biopsy of blue-stained SNs, a gastrectomy with a D2 lymphadenectomy was performed. All dissected lymph nodes were evaluated for metastasis. The results of the SN biopsies were compared between the SS and SM dye injection methods.ResultsDetection rate (0.92 vs 0.94), mean number of SNs (2.5 vs 2.9) and sensitivity (0.61 vs 0.46) of the SN biopsies were not significantly different between the SS and SM injection methods (P>0.05). The operation time was significantly shorter in the SS than the SM injection method (159.7 vs 172.7 min, P=0.030).ConclusionsBoth injection methods were equally efficient in their roles for a SN biopsy in gastric cancer. However, the SS injection method was more preferable due to its easy technique and short operation time. |
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