新型冠状病毒肺炎免疫治疗药物托珠单抗的作用机制及安全性风险分析

目的分析托珠单抗的安全性风险,为临床合理用药提供参考。方法对世界卫生组织药品不良反应监测数据库、我国药品不良反应监测数据库、国内文献数据库中的不良反应报告情况及国外药监机构风险控制措施等相关资料进行整理与分析。结果应重视托珠单抗临床使用中可能发生的肝功能异常、皮肤损害、过敏反应、胃肠道损害、感染、血液系统损害等不良反应。结论托珠单抗临床使用中,应加强对严重感染及肝功能损害等严重不良反应的安全性监测,促进药品的临床合理使用。

Mechanism and Safety Risk of Anti-novel Coronavirus Pneumonia Drug-tocilizumab

Objective To analyze the risk of tocilizumab when used in China in order to provide reference for clinical rational drug use.Methods The individual adverse drug reaction cases reported by WHO Vigilyze and China adverse drug reaction database,domestic literature and risk management plans of foreign regulatory agencies were analyzed.Results The risk of hepatic dysfunction,cutaneous damage,anaphylactic reaction,gastrointestinal disorders,infection and hematological damage should be guarded against.Conclusion We should reinforce the safety monitoring of tocilizumab by focusing on such adverse reactions as serious infections and liver damage,and promote the rational application of this medicine.