Inactivation of nontuberculous mycobacteria by gaseous ozone treatment |
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| Institution: | 1. Department of Infectious Diseases, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan;2. Division of Pharmacodynamics, Keio University Faculty of Pharmacy, Minato-ku, Tokyo, Japan;3. Keio University Health Center, Shinjuku-ku, Tokyo, Japan;1. Department of Laboratory Medicine, Tohoku University Hospital, Sendai, Japan;2. Department of Microbiology and Infectious Diseases, Faculty of Medicine, Toho University, Tokyo, Japan;3. Department of Infectious Diseases, Tohoku University Hospital, Sendai, Japan;4. Division of Crisis Management Network for Infectious Diseases, Tohoku Medical and Pharmaceutical University, Sendai, Japan;5. Department of Infectious Diseases, Tohoku Medical and Pharmaceutical University, Sendai, Japan;1. Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan;2. Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan;3. Department of Pediatrics, Tokyo Women''s Medical University Yachiyo Medical Center, 477-96, Owadashinden, Yachiyo-city, Chiba, 276-8524, Japan;4. Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan;5. Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan;6. Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu City, Shizuoka, 431-3192, Japan;1. Department of Pharmacy, Musashino Red Cross Hospital, 1-26-1, Kyonancho, Musashino-shi, Tokyo, 180-8610, Japan;2. Department of Pediatrics, Musashino Red Cross Hospital, 1-26-1, Kyonancho, Musashino-shi, Tokyo, 180-8610, Japan;3. Department of Infection Control, Musashino Red Cross Hospital, 1-26-1, Kyonancho, Musashino-shi, Tokyo, 180-8610, Japan;1. Department of Clinical Laboratory Medicine, Saitama Medical University Hospital, Saitama, Japan;2. Department of General Internal Medicine, Saitama Medical University Hospital, Saitama, Japan;3. Department of Nephrology, Saitama Medical University Hospital, Saitama, Japan;4. Department of Endocrinology and Diabetes, Saitama Medical University Hospital, Saitama, Japan;5. Department of Gastroenterology and Hepatology, Saitama Medical University Hospital, Saitama, Japan;6. Department of Rheumatology and Applied Immunology, Saitama Medical University Hospital, Saitama, Japan;7. Department of Respiratory Medicine, Saitama Medical University Hospital, Saitama, Japan;8. Department of Neurology, Saitama Medical University Hospital, Saitama, Japan;9. Department of Plastic, Reconstructive and Aesthetic Surgery, Saitama Medical University Hospital, Saitama, Japan;10. Department of Infectious Disease and Infection Control, Saitama Medical University Hospital, Saitama, Japan;1. Department of Biostatistics and Bioinformatics, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;2. Department of Eat-loss Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;3. Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;4. Department of Biostatistics and Bioinformatics, Interfaculty Initiative in Information Studies, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;5. Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Bunkyo-ku, Tokyo, Japan;1. Department of Infectious Diseases, ASST Fatebenefratelli Sacco, Via Giovanni Battista Grassi 74, 20157, Milan, Italy;2. Luigi Sacco Department of Biomedical and Clinical Sciences, University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy;3. Synlab Italia, Via Martiri delle Foibe 1, 20900, Monza, Italy;4. Synlab Data Medica Padova, Via Antonio Zanchi 89, 35133, Padova, Italy |
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| Abstract: | Nontuberculous mycobacteria (NTM) are environmental bacteria resistant to many common disinfectants and ultraviolet radiation. Inhalation of aerosols generated from NTM-containing water and soil causes NTM lung disease, especially in people with underlying lung diseases and decreased immunity. To prevent healthcare-acquired NTM infections, it is important to eradicate NTM living in hospital environments. Therefore, we evaluated the efficacy of gaseous ozone for the inactivation of NTM, namely Mycobacterium (M.) avium, M. intracellulare, M. kansasii, M. abscessus subsp. abscessus and M. abscessus subsp. massiliense. Gaseous ozone treatment at 1 ppm for 3 h reduced the bacterial number of all strains by more than 97%. Gaseous ozone treatment could be a practical, effective and convenient disinfection method for NTM living in hospital environments. |
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| Keywords: | Nontuberculous mycobacteria Gaseous ozone Disinfection |
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