Comprehensive commissioning and quality assurance validation of Ethos™ therapy |
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| Institution: | 1. Radiation therapy department, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France;2. Hematology department, Gustave-Roussy, 114, rue Édouard-Vaillant, 94800 Villejuif, France;3. Internal medicine department, hôpital Bicêtre, AP–HP, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, France;1. Laboratoire d’imagerie translationnelle en oncologie (Lito), Institut Curie, université PSL, université Paris Saclay, Inserm, 91898 Orsay, France;2. Département de radiothérapie oncologique, institut Curie, université PSL, Centre de protonthérapie, centre universitaire, 91898 Orsay, France;3. Département d’oncologie médicale, institut Curie, Paris, France;4. Département de radiothérapie oncologique, institut Curie, université PSL, Paris, France;1. Radiotherapy department, centre hospitalier de Saint-Quentin, 1, avenue Michel-de-l’Hospital, 02100 Saint-Quentin, France;2. Medical Physics Department, centre hospitalier de Saint-Quentin, 1, avenue Michel-de-l’Hospital, 02100 Saint-Quentin, France;3. Radiology Department, centre hospitalier de Saint-Quentin, 1, avenue Michel-de-l’Hospital, 02100 Saint-Quentin, France;4. Neurology Department, centre hospitalier de Saint-Quentin, 1, avenue Michel-de-l’Hospital, 02100 Saint-Quentin, France;1. ORLAM group, Department of Radiation Oncology, 44 rue Ambroise Paré, 71000 Mâcon, France;2. Vision RT Ltd, Dove House, Arcadia Avenue, London N3 2JU, UK;1. Centre of Diagnostic, Therapeutic and Investigative Sciences (CODTIS). Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Aziz, Kuala Lumpur 50300 Malaysia;2. Functional Image Processing Laboratory, Department of Radiology, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur 56000, Malaysia |
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| Abstract: | PurposeAdaptive radiotherapy with the Ethos® therapy Varian system has been recently implemented at the Montpellier Cancer Institute, France. This article details the commissioning performed before the implementation of this new treatment planning system (TPS).Material and methodsTo validate the golden beam data of the machine (Halcyon linear accelerator), percentage depth doses (PDD) and profiles were measured for several field sizes and at different depths with a microdiamond chamber. The final doses calculated for different plan types with the Ethos Acuros XB algorithm and the Halcyon Eclipse Analytic Anisotropic Algorithm were compared using the gamma index method. Lastly, for the patient quality assurance (QA) process, the patient treatment plan results obtained with the Mobius3D QA platform (Varian) were compared with the portal dosimetry results obtained with Epiqa (Epidos).ResultsMinor differences were observed for the PDD and profile curves (mean difference of 0.2% and 2%, respectively). The χ index pass rate was above 98% for all measures using the 1%/1 mm and 2%/2 mm criteria for PDD and profile evaluations. The Ethos AXB algorithm was validated for every configuration (fixed fields, standard IMRT and VMAT fields, and clinical plans) with 2D/3D gamma index values > 99%. Seventy-three 3-arcs-VMAT QA plans and 27 9-fields-IMRT QA plans were evaluated. Both showed excellent agreement with the TPS calculations (mean gamma pass rate higher than 99%). No difference was observed between IMRT and VMAT.ConclusionThe beam delivery, the Ethos AXB algorithm, and the patient QA were comprehensively validated using independent tools. |
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| Keywords: | Ethos™ Commissioning QA validation Ethos™ Commissioning Assurance qualité |
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