Endogenous neurotrophin-3 promotes neuronal sprouting from dorsal root ganglia |
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| Authors: | Xu-yang Wang Pei-yuan Gu Shi-wen Chen Wen-wei Gao Heng-li Tian Xiang-he Lu Wei-ming Zheng Qi-chuan Zhuge Wei-xing Hu |
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| Institution: | 1.Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China;2.Department of Neurosurgery, Shanghai Jiao Tong University Affiliated 6th People''s Hospital, Shanghai, China;3.Department of Neurosurgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China |
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| Abstract: | In the present study, we investigated the role of endogenous neurotrophin-3 in nerve terminal sprouting 2 months after spinal cord dorsal root rhizotomy. The left L1–5 and L7–S2 dorsal root ganglia in adult cats were exposed and removed, preserving the L6 dorsal root ganglia. Neurotrophin-3 was mainly expressed in large neurons in the dorsal root ganglia and in some neurons in spinal lamina II. Two months after rhizotomy, the number of neurotrophin-3-positive neurons in the spared dorsal root ganglia and the density of neurite sprouts emerging from these ganglia were increased. Intraperitoneal injection of an antibody against neurotrophin-3 decreased the density of neurite sprouts. These findings suggest that endogenous neurotrophin-3 is involved in spinal cord plasticity and regeneration, and that it promotes axonal sprouting from the dorsal root ganglia after spinal cord dorsal root rhizotomy. |
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| Keywords: | nerve regeneration neurotrophin-3 sensory neurons dorsal root ganglion cats nerve terminal neural regeneration |
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