| 肾素-血管紧张素系统在COVID-19中作用及药物干预 |
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| 引用本文： | 李思铮,胡广,何敬成,胡宇驰,李志勇,靳洪涛.肾素-血管紧张素系统在COVID-19中作用及药物干预[J].中国药物警戒,2020(5):267-271. |
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| 作者姓名： | 李思铮 胡广 何敬成 胡宇驰 李志勇 靳洪涛 |
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| 作者单位： | 中国医学科学院药物研究所新药安全评价研究中心;南开大学药学院;南方医科大学顺德医院;北京市药品检验所;中央民族大学药学院;北京协和建昊医药技术开发有限责任公司 |
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| 基金项目： | 重大新药创制专项(2018ZX09201017-005,2018ZX09711001-002-001,2018ZX09711001-011):吸入毒性和儿童用药等特色创新药物安全性评价关键技术研究;新技术新方法在药物毒性中的应用,十三五重大专项定向委托项目-尘肺治疗药物和防治关键技术研究;中国医学科学院医学与健康科技创新工程项目(2017-I2M-1-01)。 |
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| 摘 要： | COVID-19的发病特征为发热、干咳、乏力,严重者可进展为急性呼吸窘迫综合征(ARDS)等,甚至危及生命。SARS-CoV-2可通过血管紧张素转化酶2(ACE2)入侵细胞并导致ACE2表达下调。ACE2表达下调会导致肾素-血管紧张素系统(RAS)的失衡,从而引起后续病理状态发生,RAS在ARDS中也发挥重要的作用。本文总结了RAS系统在COVID-19发病过程中可能存在的作用,以及基于RAS对于COVID-19的治疗可能,为优化治疗及后续研究提供参考。
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| 关 键 词： | COVID-19 血管紧张素转化酶2 肾素-血管紧张素系统 肺损伤 病理作用 研究进展 |
The Role of Renin-angiotensin System in COVID-19 and Drug Intervention |
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| LI Sizheng,HU Guang,HE Jingcheng,HU Yuchi,LI Zhiyong,JIN Hongtao.The Role of Renin-angiotensin System in COVID-19 and Drug Intervention[J].Chinese JOurnal of Pharmacovigilance,2020(5):267-271. |
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| Authors: | LI Sizheng HU Guang HE Jingcheng HU Yuchi LI Zhiyong JIN Hongtao |
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| Institution: | (New Drug Safety Evaluation Center,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;College of Pharmacy,Nankai University,Tianjin 300350,China;Shunde Hospital of Southern Medical University,Foshan Guangdong 528000,China;Beijing Institute For Drug Control,Beijing 102206,China;School of Pharmacy,Minzu University of China,Beijing 100081,China;Beijing Union-Genius Pharmaceutical Technology Co.,Ltd,Beijing 100176,China) |
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| Abstract: | The pathogenesis of COVID-19 is characterized by fever,dry cough and fatigue.In severe cases,it may progress to acute respiratory distress syndrome(ARDS),etc.,and even death.SARS-CoV-2 can invade cells through angiotensin-converting enzyme 2(ACE2)and cause down-regulation of ACE2 expression.The down-regulation of ACE2 expression can lead to the imbalance of renin-angiotensin system(RAS),which leads to the occurrence of subsequent pathological states.RAS also plays an important role in ARDS.This review summarized the possible roles of RAS in the pathogenesis of COVID-19,as well as treatment of COVID-19 based on RAS,hoping to optimize the treatment and provide reference information. |
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| Keywords: | COVID-19 angiotensin-converting enzyme 2 renin-angiotensin system lung injury pathological effects research progress |
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