First report of Mycobacterium virginiense-induced synovitis and tenosynovitis of flexor digitorum superficialis and profundus muscles in Japan |
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| Affiliation: | 1. Department of Infection Control Science, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan;2. Department of Infectious Disease Medicine, Osaka Metropolitan University Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan;3. Department of Infection Control and Prevention, Osaka Metropolitan University Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan;4. Department of Orthopedic Surgery, Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka, 545-8585, Japan;5. Department of Orthopedic Surgery, Osaka Metropolitan University Hospital, 1-5-7 Asahi-machi, Abeno-ku, Osaka, 545-8586, Japan;1. Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development, 2-10-1, Okura, Setagaya-ku, Tokyo, 157-8535, Japan;2. Department of Health Services Research, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan;3. Department of Pediatrics, Tokyo Women''s Medical University Yachiyo Medical Center, 477-96, Owadashinden, Yachiyo-city, Chiba, 276-8524, Japan;4. Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan;5. Department of Health Policy and Informatics, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan;6. Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1, Handayama, Higashi-ku, Hamamatsu City, Shizuoka, 431-3192, Japan;1. Department of Pharmacy, National Hospital Organization Osaka National Hospital, Japan;2. AIDS Medical Center, National Hospital Organization Osaka National Hospital, Japan;3. Department of Infectious Diseases, National Hospital Organization Osaka National Hospital, Japan;4. Department of Advanced Medicine for HIV Infection, Osaka University Graduate School of Medicine, Japan;1. Disease Control and Prevention Center, National Center for Global Health and Medicine, Tokyo, Japan;2. Clinical Laboratory, National Center for Global Health and Medicine, Tokyo, Japan;3. Department of Respiratory Medicine, National Center for Global Health and Medicine, Tokyo, Japan;4. Department of Orthopedic Surgery, Center Hospital of the National Center for Global Health and Medicine, Japan;1. Department of Pharmacy, Musashino Red Cross Hospital, 1-26-1, Kyonancho, Musashino-shi, Tokyo, 180-8610, Japan;2. Department of Pediatrics, Musashino Red Cross Hospital, 1-26-1, Kyonancho, Musashino-shi, Tokyo, 180-8610, Japan;3. Department of Infection Control, Musashino Red Cross Hospital, 1-26-1, Kyonancho, Musashino-shi, Tokyo, 180-8610, Japan;1. Microbiology Department, Middlemore Hospital, Auckland, New Zealand;2. Infectious Diseases Department, Middlemore Hospital, Auckland, New Zealand;1. Infection Control Center, Oita University Hospital, Japan;2. Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine, Japan |
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| Abstract: | Mycobacterium virginiense, a species of the Mycobacterium terrae complex, was first identified in 2016. Although M. virginiense has only been reported to cause tenosynovitis, there have been only a few reports. Moreover, there is no established standard treatment, and no cases of M. virginiense infection have been reported in Japan. A 70-year-old Japanese man with a history of hand injury and wound contamination was diagnosed with synovitis and tenosynovitis of the left flexor digitorum superficialis and profundus muscles. M. virginiense was detected in perisynovial reservoirs and surgically removed synovium and was identified by hsp65 and rpoB sequencing. Postoperative chemotherapy with clarithromycin, rifabutin, and ethambutol was administered. Infection with M. virginiense can occur in patients with synovitis and tenosynovitis who have experienced injury or wound contamination, requiring surgery and long-term treatment with multiple antibiotics. |
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| Keywords: | Synovitis Tenosynovitis MIC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" minimum inhibitory concentration MTC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," $$" :[{" #name" :" italic" ," _" :" Mycobacterium terrae" },{" #name" :" __text__" ," _" :" complex |
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