阻塞性睡眠呼吸暂停低通气综合征儿童行为异常与血清C反应蛋白的相关性研究

目的：探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）儿童行为异常的发病机制。方法：对70例4～11岁打鼾儿童进行整夜多导睡眠仪监测,诊断为OSAHS40例,单纯鼾症30例,并以40例健康儿童为对照组。应用Conners简明症状问卷评定儿童行为问题。采用速率散射比浊法检测以上各组儿童血清C反应蛋白的含量。结果：OSAHS及单纯鼾症组存在行为问题的比率明显高于健康对照组,而两组之间差异无统计学意义。OSAHS组C反应蛋白含量（4.24mg/L）明显高于单纯鼾症组（2.76mg/L）及健康对照组（1.27mg/L）;单纯鼾症组C反应蛋白含量高于健康对照组。OSAHS组伴有行为异常者血清C反应蛋白含量（4.63mg/L）明显高于不伴有行为异常者（3.23mg/L）;单纯鼾症组伴有行为异常者血清C反应蛋白含量（3.63mg/L）明显高于不伴有行为异常者（1.76mg/L）。结论：OSAHS及单纯鼾症儿童有较多的行为问题出现。C反应蛋白的升高与OSAHS及单纯鼾症儿童的行为异常具有相关性。

The relationship between the abnormal behavior and serum C-reactive protein in children with obstructive sleep apnea-hypopcea syndrom

Objective:To explore the pathogenesis of abnormal behavior in children with obstructive sleep apnea-hypopnea syndrome(OSAHS).Method:The behavioral problems and C-reactive protein were measured in 40 children with OSAHS and 30 children with habitual snoring who underwent overnight Polysomnography,40 cases of healthy children for the control group.Result:The ratio of abnormal behavior in OSAHS and abitual snoring children was significantly higher than that of the healthy control group,while no significant difference between the two groups.The content of C-reactive protein in OSAHS children(4.24 mg/L)was significantly higher than habitual snoring(2.76mg/L)and healthy control group(1.27mg/L);in habitual snoring children C-reactive protein was higher than in healthy control group.The content of serum C-reactive protein in OSAHS children accompanied by abnormal behavior(4.63 mg/L)was significantly higher than that without abnormal behavior(3.23 mg/L).The content of serum C-reactive protein content in habitual snoring children accompanied y abnormal behavior (3.63 mg/L)was significantly higher than that without abnormal behavior(1.76 mg/L).Conclusion:OSAHS and habitual snoring children have more behavior problems.C-reactive protein levels are higher in children with OSAHS and habitual snoring.and the levels of C-reactive protein are related to the abnormal ehavior in these children.