A comparison of oral omeprazole and intravenous cimetidine in reducing complications of duodenal peptic ulcer |
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| Authors: | Manouchehr Khoshbaten Ebrahim Fattahi Nosratollah Naderi Farzaneh Khaleghian Mohammadreza Rezailashkajani |
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| Affiliation: | (1) Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;(2) Drug Applied Research Center (DARC), Tabriz University of Medical Sciences, Tabriz, Iran;(3) Research Center for Gastroenterology and Liver Diseases, Shaheed Beheshti University of Medical Sciences, Tehran, Iran;(4) Tabriz University of Medical Sciences, Tabriz, Iran |
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| Abstract: | Background Gastrointestinal bleeding is a common problem and its most common etiology is peptic ulcer disease. Ulcer rebleeding is considered a perilous complication for patients. To reduce the rate of rebleeding and to fasten the improvement of patients' general conditions, most emergency departments in Iran use H2-blockers before endoscopic procedures (i.e. intravenous omeprazole is not available in Iran). The aim of this study was to compare therapeutic effects of oral omeprazole and intravenous cimetidine on reducing rebleeding rates, duration of hospitalization, and the need for blood transfusion in duodenal ulcer patients. |
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