Methylation status of O6-methylguanine-DNA-methyl transferase promoter region in non-small-cell lung cancer patients with brain metastasis |
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| Authors: | Kenji Hashimoto Yoshitaka Narita Yuko Matsushita Yasuji Miyakita Makoto Ono Takamasa Kayama Soichiro Shibui |
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| Affiliation: | Neurosurgery Division, National Cancer Center Hospital, Tokyo 104-0045, Japan. gonmusao@k6.dion.ne.jp |
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| Abstract: | Background O6-methylguanine-DNA-methyl transferase (MGMT), a DNA repair gene, is a key enzyme for predicting the response to both radiotherapy and temozolomide in glioma patients. Data on the MGMT promoter methylation status in relation to the time to develop intracranial new metastasis or local relapse at the surgical site after brain surgery followed by radiotherapy is limited in non-smallcell lung cancer (NSCLC) patients with a single brain metastasis. |
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