| 遍地金提取物对大鼠脑纹状体突触体[3H]-多巴胺重摄取抑制试验 |
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| 引用本文： | 赵晶,何洪静,高玮,李全红,赵见宝. 遍地金提取物对大鼠脑纹状体突触体[3H]-多巴胺重摄取抑制试验[J]. 药学实践杂志, 2002, 20(6): 338-340 |
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| 作者姓名： | 赵晶 何洪静 高玮 李全红 赵见宝 |
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| 作者单位： | 1. 成都军区昆明总医院,昆明,650032
2. 大理医学院98级 |
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| 摘 要： | 目的:评价遍地金提取物对大鼠脑纹状体突触体[3H]-多巴胺重摄取的抑制作用。方法:通过大鼠脑纹状体突触体[3H]-多巴胺重摄取抑制实验,测定其重摄取量cmp及抑制百分率,以评价待试物对多巴胺重摄取的抑制活性。结果:遍地金组平均抑制百分率为65％,IC50=113.25mg·ml-1;St.John's Wort组平均抑制百分率为61％,IC50=28.29mg·ml-1。结论:遍地金提取物与在欧美上市的药物 St.john's Wort均抑制大鼠脑纹状体突触体[3H]-多巴胺重摄取,二者差异无统计学意义。
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| 关 键 词： | 遍地金提取物 大鼠 脑纹状体 突触体 多巴胺 重摄取 抑制百分率 |
| 文章编号： | 1006-0111(2002)06-0338-03 |
| 收稿时间： | 2002-08-27 |
| 修稿时间： | 2002-08-27 |
Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain |
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| ZHAO Jing,HE Hong-Jing,GAO Wei,LI Quan-Hong and ZHAO Jian-Bao. Effect of Hypericum Wightianum extracts on synapse reuptake of dopamine in the striatum of rat brain[J]. The Journal of Pharmaceutical Practice, 2002, 20(6): 338-340 |
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| Authors: | ZHAO Jing HE Hong-Jing GAO Wei LI Quan-Hong ZHAO Jian-Bao |
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| Affiliation: | Kunming Military General Hospital, Kunming 650032, China;Kunming Military General Hospital, Kunming 650032, China;Kunming Military General Hospital, Kunming 650032, China;The Pharmaceutical Department of Dali Medical University;The Pharmaceutical Department of Dali Medical University |
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| Abstract: | OBJECTIVE: To study effect of hypericum wightianum extracts on synapse reuptake of dopamine in rat brain striatum. METHODS:The inhibition experiment of reuptaking [3H] -dopamine on brain striatum synapse of rat has been adopted. The activity was evaluated by assaying quantity of reuptaking(cmp) and the inhibition percentage. RESULTS:The average inhibition percentage and IC50 of Hypericum Wightianum extract group,are respectively 65% and 113. 25 mg/ml and for St. Johns 61% and 28. 29mg-ml-1 and for Wort group are. CONCLUSION :Hypericum Wightianum extract group and antidepressant preparation St. John's Wort group both showed inhibition activity on brain striatum synapse reuptaking dopamine and have no statistics significance between the two groups. |
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| Keywords: | Hypericum Wightianum dopamine reuptake inhibition percentage |
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