加减葛根汤治疗外寒内热型上呼吸道感染的临床研究

目的观察加减葛根汤治疗外感风寒内蕴郁热型上呼吸道感染的临床疗效。方法观察外感风寒内蕴郁热型上呼吸道感染病例91例，其中治疗组47例，对照组44例。治疗组予加减葛根汤，1次·8h-1；对照组予复方盐酸伪麻黄碱缓释胶囊1粒，1次·12h-1。疗程3d。并进行治疗前后中医证候评分及体温评分的比较。结果治疗组平均降温起效时间为6．52h，退热时间18．29h；对照组平均降温起效时间为8．64h，退热时间24．00h。两组降温起效时间、退热时间比较，差异均有统计学意义（P〈0．05）。体温疗效，治疗组总有效率100％，对照组总有效率47．73％。中医证候疗效，治疗组总有效率85．11％，对照组总有效率63．64％。两组上呼吸道感染体温疗效、中医证候疗效分析比较，差异有统计学意义（P〈0．05）。结论加减葛根汤对于外感风寒内蕴郁热型上呼吸道感染的退热效果及临床疗效优于复方盐酸伪麻黄碱缓释胶囊。

Clinical Research of the Upper Respiratory Tract Infection of the External Cold and Internal Heat Pattern/Syndrome Treated with the Modified Radix Puerariae Decoction

Objective To observe the clinical efficacy of the modified radix puerafiae decoction in the treatment of the upper respiratory tract infection （URTI） differentiated as the invasion of the exogenous wind cold and the internal retention of heat. Methods 91 cases of URTI differentiated as the invasion of the exogenous wind cold and the internal retention of heat were included in the observation, of which, 47 cases were in a treatment group and 44 cases in a control group. In the treatment group, the modified radix puerariae decoction was prescribed, 1 dose/8 h. In the control group, the compound pseudoephedfine HCI sustained re- lease capsules were prescribed, 1 capsule/12 h. The duration of treatment was 3 days. The Chinese medicine symptom score and the body temperature score were compared before and after treatment. Results In the treatment group,the average onset time of hypothermia was 6.52 h and the pyreto]ysis time was 18.29 h. In the control group, the average onset time of hypothermia was 8.64 h and the pyretolysis time was 24 ： 00 h, presenting the statistical significant differences in comparison （ P 〈 0.05 ）. Concerning to the effect on the body temperature,the total effective rate was 100% in the treatment group and was 47.73% in the control group. Concerning to the effect on Chinese medicine symptoms, the total effective rate was 85.11% in the treatment group and was 63.64% in the control group. The statistical significant differences presented in the effects on the body temperature and Chinese medicine symptoms of URTI between two groups （ P 〈 0.05 ）. Conclusion The modified radix puerariae decoction achieves the superior pyretolysis effect and clinical effi- cacy on URTI differentiated as the invasion of the exogenous wind cold and the internal retention of heat as compared with the compound pseudoephedrine HCI sustained release capsules.