雌激素受体亚型与子宫内膜癌预后因素的关系

目的　研究子宫内膜癌组织中 ERα m RNA和 ERβ m RNA表达状况及其与子宫内膜癌预后因素的关系。方法　用双重 RT- PCR测定 4 1例子宫内膜癌组织中 ERα m RNA和 ERβ m RNA的表达 ,分析 ERα/ ERβm RNA比值与子宫内膜癌预后因素的关系。结果　 4 1例子宫内膜癌组织中 ERα m RNA阳性率为 95 % (39/ 4 1) ,ERβ m RNA阳性率为 90 .2 % (37/ 4 1)。 ERα/ ERβ>1者 2 1例、占 5 1.2 % ,ERα/ ERβ<1者 14例、占 34.1%。 ERα/ERβ m RNA比值与子宫内膜癌预后因素相关。结论　 ERα m RNA相对高表达 (ERα/ ERβ>1)可能是子宫内膜癌预后良好的指标。 ERβ m RNA相对高表达 (ERα/ ERβ<1)可能与子宫内膜癌预后不良有关。

Association Between the Expression of Estrogen Receptor Subunit in Endometrial Carcinoma and the Prognostic Factors of Endometrial Carcinoma

OBJECTIVE: To study the relationship between the expression of ERalpha and ERbeta mRNA in the fresh tissue from patients with endometrial carcinoma and to evaluate the association between the ratio of ERalpha/ERbeta and the prognostic factors of endometrial carcinoma. METHODS: Multiplex RT-PCR was used to study the expression of ERalpha and ERbeta mRNA in the fresh endometrial tissue from 41 cases of endometrial carcinoma. The association between the expression of ERalpha/ERbeta mRNA and the prognostic factors of endometrial carcinoma was evaluated. RESULTS: ERalpha mRNA and ERbeta mRNA were detected in 95% and 90.2% of the 41 cases of endometrial carcinoma, respectively. ERalpha/ERbeta > 1 was detected in 21 cases and ERalpha/ERbeta < 1 was detected in 14 cases. Analysis revealed an association between the ratio of ERalpha/ERbeta mRNA and the prognostic factors of endometrial carcinoma. CONCLUSION: In this study, ERalpha mRNA overexpression (ERalpha/ERbeta > 1) was found associated with good prognostic factors of endometrial carcinoma, whereas ERbeta mRNA overexpression (ERalpha/ERbeta < 1) was found associated with poor prognostic factors of endometrial carcinoma.