Cytogenetic and genetic effects of subchronic treatments with organophosphorus insecticides |
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| Authors: | Noël Degraeve Marie-Christine Chollet Jean Moutschen |
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| Affiliation: | (1) Laboratoire de Chimie Médicale, Institut de Pathologie, B 23 Université de Liège, B-4000 Sart Tilman par Liège 1, Belgium;(2) Laboratoire de Génétique, Université de Liège, 15 rue Forgeur, B-4000 Liège, Belgium |
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| Abstract: | Male mice (Q strain) received 5 days a week for 7 weeks drinking water containing dichlorvos (2 ppm), dimethoate (0.6 ppm), malathion (8 ppm), methylparathion (0.15 ppm), or trichlorfon (0.5 ppm). At the end of the treatment, no chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. Dominant lethal mutation assays were performed to investigate the pre- and postimplantation foetal lethality. Only negative results were obtained. |
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| Keywords: | Subchronic treatments Genetic and cytogenetic effects Organophosphorus insecticides |
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