前列腺增生症所致膀胱出口梗阻患者膀胱平滑肌中bFGF的表达变化

患者膀胱平滑肌中碱性成纤维细胞生长因子（basic fibroblast growth factor,bFGF）的表达变化。方法:同龄对照组16例患者、BPH梗阻逼尿肌稳定组24例患者和BPH梗阻逼尿肌不稳定组16例患者的膀胱壁逼尿肌组织，应用免疫组织化学SABC法检测膀胱平滑肌细胞中bFGF蛋白的表达变化。结果:bFGF在同龄对照组、BPH梗阻逼尿肌稳定组和梗阻逼尿肌不稳定组患者的膀胱平滑肌细胞中均有表达。BPH梗阻逼尿肌稳定组和梗阻逼尿肌不稳定组bFGF的表达水平均高于同龄对照组，差异有统计学意义（P＜0.05)，但BPH梗阻逼尿肌稳定组与梗阻逼尿肌不稳定组bFGF表达水平的差异无统计学意义（P＞0.05）。结论:BPH引起BOO后，膀胱平滑肌细胞中bFGF的表达水平增高与膀胱平滑肌细胞的肥大以及平滑肌细胞间胶原纤维的增多有关，但可能与逼尿肌不稳定的发生无关。

hanges of basic fibroblast growth factor in bladder smooth muscle in patients

Objective: To investigate the changes of basic fibroblast growth factor(bFGF) in human bladder smooth muscle in patients with bladder outlet obstruction(BOO) induced by benign prostatic hyperplasia(BPH).Methods: Sixteen patients with other diseases and forty patients with BPH were included in this study.All patients were divided into three groups,a control group,an obstructive detrusor stability group and an obstructive detrusor instability group.bFGF was measured using an immunohistochemical study.Results: The immunohistochemical study indicated that bFGF was expressed in cytoplasm of bladder smooth muscle cells.The expression of bFGF in the obstructive detrusor stability group and in the obstructive instability group were significantly higher than in the control group (P<0.05).But there was no significant difference between the obstructive detrusor stability group and the obstructive instability group(P>(0.05)).Conclusion: The increased bFGF level of bladder smooth muscle cells is correlated with the alterations of bladder detrusor due to BOO,but may not relate to the detrusor instability.