新生儿红细胞葡萄糖-6-磷酸脱氢酶缺乏症临床分析

分析昆明地区新生儿葡萄糖－6－磷酸脱氢酶（glucose-6-phosphate dehydrogenas,G6PD）缺乏症与新生儿黄疸的关系，探讨发生新生儿黄疸的诱因、机制以及临床表现差异的原因，利用经皮测黄疸仪测定14例G6PD缺乏症新生儿及28例正常新生儿第1，3，5d黄疸指数并进行比较，对两组新生儿围产因素进行比较。结果：两组新生儿第1，3d黄疸指数的比较无显著性差异，第5d黄疸指数的比较有显著性差异；两组新生儿剖宫产，胎儿宫内窘迫，新生儿窒息等转产因素发生率的比较无显著性差异，两组新生儿高胆红素血症发生率的比较无显著性差异。结论：昆明地区G6PD缺乏症新生儿病理性黄疸的发生率较低，且黄疸程度较轻，但进展快，临床表现可从无症状基因携带者到核黄疸，进行G6PD缺乏症新生儿的脐血筛查，提高对本病的认识以及及时治疗是减轻新生儿病理性黄疸发生率和核黄疸发生率的有效途径。

The Clinical Analysis of Glucose-6-phosphate Dehydrogenase Deficiency of Neonates

The aim of this paper is to compare the serum bilirubin levels between G6PD deficient neonates and normal neonates. 14 G6PD deficient neonates formed the study group, while 56 neonates with normal levels of the enzyme formed the control group. Neonates with jaundice from any other identifiable cause were excluded. We compared the serum bilirubin levels between the two groups. The serum bilirubin of the fifth day of the G6PD deficient neonates was higher than control group(P<0 05). The incidence of neonatal hyperbilirubinemia of Kunming region was lower. The earlier treatment and diagnosis of G6PD deficient neonates, the lower incidence of neonatal hyperbilirubinemia.