| 聚苯乙烯负载三氯化铁催化制备碳水化合物O-异亚丙基衍生物的改良方法 |
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| 引用本文： | 谢斌,陈芬儿. 聚苯乙烯负载三氯化铁催化制备碳水化合物O-异亚丙基衍生物的改良方法[J]. 中国药物化学杂志, 2008, 18(2): 109-111 |
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| 作者姓名： | 谢斌 陈芬儿 |
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| 作者单位： | 复旦大学化学系,上海,200433 |
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| 摘 要： | 目的改进碳水化合物。一异亚丙基衍生物的合成方法。方法各种碳水化合物与丙酮在2％交联聚苯乙烯负载三氯化铁（31．3mgFeCl3／g树脂）催化下进行异丙叉化反应。结果与结论以70％～90％的收率制得目标产物。改进后的方法具有反应条件温和、操作简便、催化剂易与反应物分离并可反复回收套用等优点。
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| 关 键 词： | 碳水化合物 聚苯乙烯负载三氯化铁 保护基 O-异亚丙基叉化反应 缩酮化反应 |
| 文章编号： | 1005-0108(2008)02-0109-03 |
| 收稿时间： | 2007-11-07 |
| 修稿时间： | 2007-11-07 |
An improved acetonation method with the polystyrene-supported FeCl3 as catalyst to the synthesis of O-isopropylidene carbohydrate derivatives |
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| XIE Bin,CHEN Fen-er. An improved acetonation method with the polystyrene-supported FeCl3 as catalyst to the synthesis of O-isopropylidene carbohydrate derivatives[J]. Chinese Journal of Medicinal Chemistry, 2008, 18(2): 109-111 |
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| Authors: | XIE Bin CHEN Fen-er |
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| Affiliation: | ( Department of Chemistry , Fudan University , Shanghai 200433 , China ) |
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| Abstract: | Aim To improve the preparation method for O-isopropylidene carbohydrate derivatives. Methods 2% Crosslinked polystyrene-supported FeCl3 (PS-FeCl3, 31.3 mgFeCl3/g resin) can be used to catalyze the acetonation of various carbohydrates. Results and conclusion This method consists of a very simple and economic experimental procedure, in which the polystyrene-supported FeCl3 catalyst can be readily recovered and reused. Reaction with carbohydrates led to the convenient formation of O-isopropylidene carbohydrate derivatives in 70%-90 % yield. |
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| Keywords: | carbohydrates；polystyrene-supported FeCl3；propective group；O-isopropylidenation；acetonation |
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