Aminopeptidase P in individuals with a history of angio-oedema on ACE inhibitors |
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Authors: | Adam Albert Cugno Massimo Molinaro Giuseppe Perez Melissa Lepage Yves Agostoni Angelo |
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Affiliation: | Faculté de Pharmacie, Université de Montréal, Montréal, Canada. albert.adams@umontreal.ca |
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Abstract: | Angio-oedema is a rare but potentially life threatening side-effect of angiotensin-converting-enzyme (ACE) inhibitor treatment. Identification of individuals at risk of this adverse effect is not possible. Angio-oedema is associated with raised concentrations of bradykinin, which is mainly inactivated by ACE. We assessed the plasma activity of two other enzymes that catabolise bradykinin (aminopeptidase P and carboxypeptidase N) in 39 hypertensive patients with a history of angio-oedema during ACE inhibitor treatment and in 39 hypertensive patients who had never had ACE inhibitor associated side-effects. Patients with previous angio-oedema had a lower plasma activity of aminopeptidase P than did those who never presented with angio-oedema (p=0 003). Our data suggest that low plasma concentrations of aminopeptidase P could be a predisposing factor for development of angio-oedema in patients treated with ACE inhibitors. |
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