| Graves病动物模型研究进展 |
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| 引用本文： | 王悦,伍丽萍,施秉银.Graves病动物模型研究进展[J].医学综述,2012,18(10):1455-1458. |
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| 作者姓名： | 王悦 伍丽萍 施秉银 |
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| 作者单位： | 西安交通大学医学院第一附属医院内分泌科 |
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| 基金项目： | 国家自然科学基金(30972701) |
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| 摘 要： | 近年Graves病(GD)动物模型的研究方法主要有:用稳定表达促甲状腺激素受体(TSHR)的细胞免疫小鼠;短暂表达TSHR的质粒免疫小鼠;转基因动物模型;单克隆抗体被动免疫诱导;用表达TSHR-A亚单位的腺病毒免疫小鼠。其中,用TSHR-A亚单位的腺病毒免疫是目前诱导GD发病率高且稳定的方法。在此基础上,还有BALB/c小鼠GD免疫耐受模型的建立。
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| 关 键 词： | Graves病 促甲状腺激素受体 动物模型 |
Research Progress of Animal Models of Graves Disease |
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| WANG Yue,WU Li-ping,SHI Bing-yin.Research Progress of Animal Models of Graves Disease[J].Medical Recapitulate,2012,18(10):1455-1458. |
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| Authors: | WANG Yue WU Li-ping SHI Bing-yin |
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| Institution: | .(Department of Endocrinology,Xi′an Jiaotong University′s First Affiliated Hospital,Xi′an 710061,China) |
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| Abstract: | In recent years,Graves disease(GD)can be induced in animals by several approaches:injecting cells stably expressing the TSH receptor(TSHR);transient vaccination with TSHR-DNA in plasmid;transgenic models;passive transfer of monoclonal antibody;vaccination with TSHR A subunit in adenoviral vectors,among which the last one is the stable method with high incidence so far,and on that basis,there is also the tolerance model of BALB/C mice GD. |
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| Keywords: | Graves disease TSH receptor Animal model |
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