持续性植物状态患者脑脊液中氨基酸类神经递质的检测 |
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摘 要: |
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关 键 词: | 高效液相色谱分析 持续性植物状态 脑脊液 氨基酸 神经递质 |
Detection of amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vegetative state] |
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Authors: | Yan-wu Guo Ru-xiang Xu |
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Institution: | Department of Neurosurgery, Institute of Neuroscience, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. dguoyanwu@163.com |
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Abstract: | OBJECTIVE: To detect the amino acid neurotransmitters in cerebrospinal fluid of patients in persistent vegetative state (PVS) to define their relation to the clinical manifestations of the patients. METHODS: The cerebrospinal fluid from 46 patients in PVS and 20 control patients were collected for detection of glutamic acid, aspartic acid, alanine and glycine by high-performance liquid chromatography. RESULTS: All the four amino acids were separated by chromatography within 25 min. The contents of all the 4 neurotransmitters in PVS group were higher than those in the control group, and their contents were inversely correlated to PVS score of the patients. The differences in the concentration of glycine and alanine were significant between PVS patients and the control patients (P<0.05). CONCLUSION: The patient's clinical manifestations are related to the contents of amino acid neurotransmitters in the cerebrospinal fluid of PVS patients. |
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